Results 151 to 160 of about 71,128 (257)

Pragmatic Clinical Trials: A Study Design for Real-World Evidence. [PDF]

Am J Nurs
Capili B, Anastasi JK.
europepmc   +1 more source

The importance of patient-reported outcomes in pragmatic clinical trials. [PDF]

J Natl Cancer Inst, 2023
Jim HSL, Brady-Nicholls R, Hershman DL.
europepmc   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Do Clinicians Have a Duty to Participate in Pragmatic Clinical Trials? [PDF]

Am J Bioeth, 2023
Garland A, Morain S, Sugarman J.
europepmc   +1 more source

Exploring individualized crovalimab dosing in PNH through in silico modelling: Potential for improved convenience and cost efficiency

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired haematopoietic stem cell disorder. Crovalimab, a complement C5‐inhibitor, is approved for PNH and can be self‐administered subcutaneously every 4 weeks, offering a more convenient route than intravenous C5‐inhibitors.
Mendy ter Avest, Simon E. Koele, Nicole C. A. J. van de Kar, Saskia M. C. Langemeijer, Rob ter Heine   +4 more
wiley   +1 more source

A framework for health systems to assess and prioritize participation in pragmatic clinical trials. [PDF]

Learn Health Syst
Morain SR, Semler MW, Casey JD.
europepmc   +1 more source

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Ethical considerations for sharing aggregate results from pragmatic clinical trials. [PDF]

Clin Trials
Morain SR, Brickler A, Ali J, O'Rourke PP, Spector-Bagdady K, Wilfond B, Rahimzadeh V, Propes C, Mehl K, Wendler D.   +9 more
europepmc   +1 more source

Intervention delivery for embedded pragmatic clinical trials: Development of a tool to measure complexity. [PDF]

Contemp Clin Trials, 2023
Staman KL, Check DK, Zatzick D, Mor V, Fritz JM, Sluka K, DeBar LL, Jarvik JG, Volandes A, Coronado GD, Chambers DA, Weinfurt KP, George SZ.   +12 more
europepmc   +1 more source

The impact of trauma‐informed teacher education

British Educational Research Journal, EarlyView.
Abstract In this study, two cohorts of university students in an employment‐based teacher education course undertook trauma‐informed education training embedded within their coursework to enhance their preparedness to work with diverse learners and their self‐efficacy for trauma‐informed teaching. With increased calls for teacher preparation programmes
Michael Witter, Tom Brunzell, Tanjin Ashraf   +2 more
wiley   +1 more source