Results 171 to 180 of about 71,128 (257)

Optimizing diversity, equity and inclusion in pragmatic clinical trials: Findings from the Pain Management Collaboratory. [PDF]

J Pain
Lovejoy TI, Midboe AM, Higgins DM, Ali J, Kerns RD, Heapy AA, Nalule EK, Pal N.   +7 more
europepmc   +1 more source

GLP‐1 Receptor Agonists and Endoscopy: Understanding Gastric Stasis, Aspiration Risk, and Contemporary Peri‐Procedural Guidance

Chronic Diseases and Translational Medicine, EarlyView.
Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig, Jason Ta, Sophie Jones, Emily Scott, Khalid Sofi, Frances Osler, Marije Jansen, Puneet Chhabra   +7 more
wiley   +1 more source

Pragmatic clinical trials for localized prostate cancer: lessons learned and "three sins". [PDF]

Front Oncol
Roach M.
europepmc   +1 more source

From Surgical Innovation to Population Impact: Robot‐Assisted Radical Prostatectomy and the Evolution of Surgical Public Health in Brazil's Unified Health System

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Brazil's Unified Health System (Sistema Único de Saúde, SUS) represents one of the world's largest universal health systems and provides a unique real‐world platform for integrating prevention, diagnosis, treatment, and survivorship across the cancer continuum.
Leonardo Oliveira Reis
wiley   +1 more source

Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials. [PDF]

Contemp Clin Trials
Marsolo KA, Cheville A, Melnick ER, Jarvik JG, Simon GE, Sluka KA, Crofford LJ, Staman KL, Richesson RL, Schlaeger JM, Curtis LH.   +10 more
europepmc   +1 more source

A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer

Cancer Nexus, EarlyView.
ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley   +1 more source

Negative spillover due to constraints on care delivery: a potential source of bias in pragmatic clinical trials. [PDF]

Trials
Mann S.
europepmc   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Bridging research and practice: enhancing regulatory decisions with pragmatic clinical trials in oncology. [PDF]

ESMO Real World Data Digit Oncol
Stewart MD, McKee AE, Herbst RS, Andrews HS, McKelvey BA, Sigal EV, Allen JD.   +6 more
europepmc   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source