Results 161 to 170 of about 71,888 (256)

Capacity building in medicines development and regulation in Africa—Overview on recent progress

British Journal of Clinical Pharmacology, EarlyView.
Aims Despite advances in health research and digital innovation, many African countries continue to face substantial resource constraints, fragmented capacity‐building efforts and a shortage of skilled professionals in medicines development and regulatory science.
Tirhani Maluleke, Emile Malan, Michael Reid, Patrick Bouic, Haylene Nell, Goonaseelan Pillai, Catriona Waitt, Bernd Rosenkranz   +7 more
wiley   +1 more source

Potential for use of Al/machine learning for pharmacovigilance: Is there a role for regulators?

British Journal of Clinical Pharmacology, EarlyView.
Christina Gao, Ashley M. Hopkins, Andrew Rowland, Stephen Bacchi   +3 more
wiley   +1 more source

Long‐acting cabotegravir and rilpivirine in people with HIV receiving chronic anticoagulation: A real‐world case series

British Journal of Clinical Pharmacology, EarlyView.
Background Long‐acting intramuscular cabotegravir plus rilpivirine (LA‐CAB + RPV) is an effective maintenance antiretroviral regimen for virologically suppressed people with HIV. However, its use in individuals receiving chronic anticoagulation is limited by concerns regarding intramuscular bleeding risk, and real‐world data are scarce.
Montserrat Laguno, Berta Torres, Maria Martínez‐Rebollar, Paula Arreba, Octavi Roman, Roger LLobet, Leire Berrocal, Alberto Foncillas, Júlia Calvo, Abiu Sempere, Ivan Chivite, Elisa de Lazzari, Josep Mallolas, Ana González‐Cordón   +13 more
wiley   +1 more source

Optimizing diversity, equity and inclusion in pragmatic clinical trials: Findings from the Pain Management Collaboratory. [PDF]

J Pain
Lovejoy TI, Midboe AM, Higgins DM, Ali J, Kerns RD, Heapy AA, Nalule EK, Pal N.   +7 more
europepmc   +1 more source

Teacher confidence and student engagement with mental health and wellbeing lessons: Learning from an iterative curriculum intervention in schools

British Educational Research Journal, EarlyView.
Abstract The mental health and wellbeing of young people has received increasing attention in both research and the wider public discourse. There has been a marked rise in mental health conditions in young people, and the burden of care is increasingly transferred onto schools and teachers.
Thomas Godfrey‐Faussett, Naomi French, Abbie Simpkin, Julian Turner, Tracey Riseborough, Natalie Coles, Ian Thompson   +6 more
wiley   +1 more source

Pragmatic clinical trials for localized prostate cancer: lessons learned and "three sins". [PDF]

Front Oncol
Roach M.
europepmc   +1 more source

Revisiting the Carbon Footprint of Single‐Use Technologies in Biomanufacturing: A Bottom‐Up Analysis Reveals a Paradigm Shift

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The biopharmaceutical industry increasingly relies on single‐use technologies (SUT) for operational flexibility. For a long time, SUT was considered more sustainable than stainless‐steel (SST) systems due to water and energy savings. This study re‐evaluates this paradigm via a detailed bottom‐up analysis of the SUT carbon footprint at the 2000 
Jan Reiners, Katharina Bruno‐Thakur, Daina Romeo, Weronika Kuśmierczyk, Ferdinand Stückler   +4 more
wiley   +1 more source

Novel approaches to recruiting clinical sites for embedded pragmatic clinical trials: Insights from the AIM-back trial. [PDF]

Contemp Clin Trials Commun
Cope TL, George SZ, Hastings SN, France C, Tumminello C, Coffman CJ, Choate A, Lentz TA.   +7 more
europepmc   +1 more source

A General Workflow for Tangential Flow Filtration Perfusion Scale‐Up

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Tangential flow filtration (TFF) perfusion using hollow‐fiber modules offers substantial advantages over other mammalian cell retention technologies. Recently, increased awareness of Starling flow has helped to enhance filtration performance to similar, or even higher levels compared to alternative technologies.
Patrick Romann, Ken Lee, Venkatesh Natarajan, Daniel Ley, Claes Nymand Nilsson, David Garcia‐Munzer, Dominik Schieman, Mahbod Hajighasemi, Alex Zaytsev, Jason Friedman, Loic Chappuis, Tobias Habicher, Colin Jaques, Alex Cohen, Matthew Gagnon, Edward Chan, Daniel J. Karst, Philip Giller, Antony Sibilia, Andrew L. Zydney, Thomas K. Villiger   +20 more
wiley   +1 more source

Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials. [PDF]

Contemp Clin Trials
Marsolo KA, Cheville A, Melnick ER, Jarvik JG, Simon GE, Sluka KA, Crofford LJ, Staman KL, Richesson RL, Schlaeger JM, Curtis LH.   +10 more
europepmc   +1 more source