Results 141 to 150 of about 71,128 (257)

Conduction of Pragmatic Clinical Trials in Routine Clinical Settings: Guidelines for Development of Protocol. [PDF]

Curr Ther Res Clin Exp
Besekar S, Jogdand S, Patel SS.
europepmc   +1 more source

Career development in pragmatic clinical trials to improve care for people living with dementia. [PDF]

J Am Geriatr Soc, 2023
Gabbard J, Sadarangani TR, Datta R, Fabius CD, Gettel CJ, Douglas NF, Juckett LA, Kiselica AM, Murali KP, McCarthy EP, Torke AM, Callahan CM.   +11 more
europepmc   +1 more source

A Large‐Scale Study on the Relation Between Multilingualism and Social Traits in Adults With and Without Autism Diagnoses

Autism Research, EarlyView.
ABSTRACT Autism Spectrum Disorder is a neurodevelopmental condition characterized by persistent difficulties in social interaction and communication alongside restricted, repetitive patterns of behavior, interests, or activities. Emerging evidence suggests that bi/multilingualism may enhance social interaction skills, yet prior research has largely ...
Margreet Vogelzang, Sean Dong Wei Gan, Jamie Setch   +2 more
wiley   +1 more source

Protecting seriously ill populations during pragmatic clinical trials. [PDF]

J Am Geriatr Soc, 2023
Teno JM, Hanson LC, Lima JC, Saliba D.
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Patient notification about pragmatic clinical trials conducted with a waiver of consent: A qualitative study. [PDF]

Clin Trials
Morain SR, Brickler A, Semler MW, Casey JD.   +3 more
europepmc   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Distinguishing Clinical and Research Risks in Pragmatic Clinical Trials: The Need for Further Stakeholder Engagement. [PDF]

Am J Bioeth, 2023
Wilfond BS, Toraman Turk S, Kraft SA, Weiss EM, Tarr PI, Schnadower D, Freedman SB.   +6 more
europepmc   +1 more source

Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators

British Journal of Clinical Pharmacology, EarlyView.
Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen, Sean Hennessy, Colleen M. Brensinger, Warren B. Bilker, Laura M. Dember, Todd A. Miano, Tat‐Thang Vo, Allison W. Willis, Charles E. Leonard   +8 more
wiley   +1 more source