Results 201 to 210 of about 1,577,570 (335)

The “Skipping Rope” Technique: A Novel Strategy for Distal Burr Entrapment During Rotational Atherectomy

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT We describe the “skipping rope technique” for managing burr entrapment during rotational atherectomy. Sequential counterclockwise rotational force is applied to the drive shaft, generating alternative torque dynamics. This maneuver provides a safe method to disengage a stuck rotaburr, offering operators an additional strategy for this ...
Thomas J. Ford, Michael Parkinson, Colm Hanratty, Simon Walsh   +3 more
wiley   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Spotlight commentary: Deprescribing in long‐term care facilities—Towards safer and smarter medication use in older adults

British Journal of Clinical Pharmacology, EarlyView.
Nataša Skočibušić, Igor Rubinić, Vera Vlahović‐Palčevski   +2 more
wiley   +1 more source

A Comparison of Regional Decisions for Doses and Administrations of New Drugs: Concordance, Discordance, and Dependencies

Clinical Pharmacology &Therapeutics, EarlyView.
Regional differences in approved drug dosages and administration are shaped by complex factors, including clinical data, prior regulatory decisions, and region‐specific considerations. This study investigated how such factors are associated with variations in approved doses across the United States Food and Drug Administration (FDA), European Medicines
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

Patient notification about pragmatic clinical trials conducted with a waiver of consent: A qualitative study. [PDF]

Clin Trials
Morain SR, Brickler A, Semler MW, Casey JD.   +3 more
europepmc   +1 more source

Advancing Pharmacometrics in Africa: Insights and Perspectives From the 2025 Pharmacometrics Africa Conference

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacometrics (PMX) in Africa has transitioned from foundational capacity‐building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC‐2025) convened key stakeholders to consolidate the continental PMX community, review progress in local ...
Babatunde Ayodeji Adeagbo, Innocent Gerald Asiimwe, Linda Chaba, Aida N. Kawuma, Francis Williams Ojara, Ochuko Maureen Orherhe, Simon Peter Asiimwe, Veshni Pillay‐Fuentes Lorente, Sharon Sawe, Cassius M. Phogole, Catriona Waitt, Samer Mouksassi, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

Distinguishing Clinical and Research Risks in Pragmatic Clinical Trials: The Need for Further Stakeholder Engagement. [PDF]

Am J Bioeth, 2023
Wilfond BS, Toraman Turk S, Kraft SA, Weiss EM, Tarr PI, Schnadower D, Freedman SB.   +6 more
europepmc   +1 more source

Automated CLL cell population detection using a weakly supervised approach and CLL MRD flow cytometry data

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Minimal/measurable residual disease detection is routinely performed as part of post‐diagnostic treatment plans for many types of cancer, for which multiparameter flow cytometry is one possible modality frequently used. We propose a machine learning approach for binary prediction of minimal residual disease status with flow cytometry data. Our
Wikum Dinalankara, Chandler Sy, Jiani Chai, Paul B. Barone, Luigi Marchionni, Paul D. Simonson   +5 more
wiley   +1 more source

Pragmatic Clinical Trials: A Study Design for Real-World Evidence. [PDF]

Am J Nurs
Capili B, Anastasi JK.
europepmc   +1 more source

The importance of patient-reported outcomes in pragmatic clinical trials. [PDF]

J Natl Cancer Inst, 2023
Jim HSL, Brady-Nicholls R, Hershman DL.
europepmc   +1 more source