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A value proposition for pragmatic clinical trials
The American Journal of Managed Care, 2022The authors examine the origin, benefits, and challenges of pragmatic clinical trials to assess the ultimate value of this research design.
Lorella, Palazzo +3 more
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Partial Entrustment in Pragmatic Clinical Trials
The American Journal of Bioethics, 2020Morain et al. (2020) tackle the difficult and fascinating question of how researchers and health systems should manage individual-level “collateral” (i.e., incidental or secondary) findings (CFs) a...
Henry S. Richardson, Mildred K. Cho
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Pragmatic Clinical Trials in Neurology
Annals of NeurologyThe need for pragmatic clinical trials evaluating therapeutic interventions in patients with neurological disease is continually increasing due to availability of multiple therapeutic interventions (comparative effectiveness), multifaceted approaches (multiple concurrent synergistic therapeutic interventions), and gaps in trial‐specific and real‐world ...
Adnan I. Qureshi +5 more
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Research and scholarly methods: Pragmatic clinical trials
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, 2021AbstractPragmatic clinical trials (PCTs) have received increased attention within health services and pharmacy practice research due to their ability to test interventions in the real world, with emphasis on implementation and scalability in diverse practice environments.
Onyeche Oche +3 more
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Making Pragmatic Clinical Trials More Pragmatic
JAMAThis Viewpoint discusses pragmatic trials and their role in developing knowledge that can be broadly applicable throughout the health care system.
Richard, Platt +2 more
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Pragmatic Clinical Trials in Plastic Surgery
Plastic & Reconstructive SurgeryThe use of pragmatic clinical trials (PCTs) has been increasing within medical and surgical research departments, but has not yet been widely implemented in plastic surgery. PCTs are similar to randomized controlled trials (RCTs) in that they both randomize patients to treatments and follow them prospectively ...
Emily R, Geis +2 more
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Ethics and Regulatory Complexities for Pragmatic Clinical Trials
JAMA, 2014Some patients do not receive the best care possible, either because research to support clinical decision making with high-quality evidence is lacking or because evidence-based practices are not routinely implemented.1 Pragmatic clinical trials (PCTs), which include patients in routine clinical practice settings and typically incorporate comparative ...
Jeremy, Sugarman, Robert M, Califf
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Choosing outcomes for clinical trials: a pragmatic perspective
Current Opinion in Critical Care, 2018Purpose of review The turn to evidence-based medicine in critical care has lead to a dramatic increase in the number of randomized clinical trials. Yet many of these trials are not showing differences on an appropriately prespecified primary outcome.
Theodore J, Iwashyna, Joanne, McPeake
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[Comparison of pragmatic clinical trials and explanatory clinical trials].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2010Clinical trials are often designed as either pragmatic or explanatory. The pragmatic clinical trials are generally used for measuring the effectiveness of a treatment in common clinical practice, while the explanatory trial for measuring the efficacy of a treatment under ideal conditions.
Yan-Hong, Zhang +2 more
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Expanding the role of the stroke nurse: a pragmatic clinical trial
Journal of Advanced Nursing, 2005Aims. This paper reports a study evaluating whether expanding a specialist nursing role to provide outreach education and support to stroke patients and carers after discharge from hospital is effective in promoting recovery.Background. Building therapeutic relationships with patients and carers is a key component of the nursing role in stroke ...
Burton, Christopher, Gibbon, Bernard
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