Results 201 to 210 of about 71,888 (256)

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Post-trial responsibilities in pragmatic clinical trials: Fulfilling the promise of research to drive real-world change. [PDF]

Learn Health Syst
Morain SR, O'Rourke PP, Ali J, Rahimzadeh V, Check DK, Bosworth HB, Sugarman J.   +6 more
europepmc   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Sustainability Assessment of Micro, Small, and Medium Enterprises: A Systematic Review and Hybrid Architecture for Credible, Salient, and Legitimate Knowledge Governance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Sustainability assessment advances corporate social responsibility toward inclusive development. Widely recognized approaches prove inadequate for micro, small, and medium enterprises (MSMEs), resulting in fragmented proliferation that hinders cumulative knowledge.
Luísa Couto Gonçalves de Souza, Laura Proença Guimarães, Maria Auxiliadora Drumond   +2 more
wiley   +1 more source

Palliative Care and Advance Care Planning Intervention Fidelity Monitoring: Methods and Lessons Learned From PCORI-Funded Large-Scale, Pragmatic Clinical Trials. [PDF]

Med Care
Verma M, Grudzen CR, Izumi S, Wenger N, El-Jawahri A, Ejem D, Aslakson RA.   +6 more
europepmc   +1 more source

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana, Ernest Musekwa, Erica‐Mari Nell, Zivanai Cuthbert Chapanduka   +3 more
wiley   +1 more source

Epidemiology of Intensive Nutritional Interventions and Restraints in Hospitalizations for Anorexia Nervosa: Annual National Trends of the United States

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Despite the clinical relevance of enteral and parenteral tube feeding and restraint use in anorexia nervosa (AN), national‐level data on their use have remained limited, particularly for total parenteral nutrition (TPN) and percutaneous endoscopic gastrostomy (PEG).
Hiroyasu Ino, Nancy S. Jecker, Yoshiyuki Takimoto, Eisuke Nakazawa   +3 more
wiley   +1 more source

Psilocybin as a Transdiagnostic Treatment for Eating Disorders and Comorbid Psychopathology: Implications for Clinical Nosology and Research Directions

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) are characterized by high rates of psychiatric comorbidity and suboptimal treatment outcomes. There remain critical gaps in research, including the exploration of effective transdiagnostic interventions. This forum article examines the potential of psilocybin treatment (PT) as a transdiagnostic intervention for
Elena Koning, Jérémie Richard, Aaron Keshen   +2 more
wiley   +1 more source

Group sequential designs for pragmatic clinical trials with early outcomes: methods and guidance for planning and implementation. [PDF]

BMC Med Res Methodol
Parsons NR, Basu J, Stallard N.
europepmc   +1 more source