Results 141 to 150 of about 2,059 (195)

Sarin intoxication elevates plasma pralidoxime

Toxicology Letters, 1985
Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication.
M D, Green, D E, Jones, D E, Hilmas
exaly   +3 more sources

Effects of atropine and pralidoxime pretreatment on serum and cardiac oxidative stress parameters in acute dichlorvos toxicity in rats

Pesticide Biochemistry and Physiology, 2010
Recent several studies have reported that oxidative stress could be an important component of the mechanism of cardiotoxicity due to organophosphate-induced toxicity.
Ozcan Bektaş, Ataman Kose, Abdullah Tuncay Demiryürek   +2 more
exaly   +2 more sources

Reactivation of Plasma Butyrylcholinesterase by Pralidoxime Chloride in Patients Poisoned by WHO Class II Toxicity Organophosphorus Insecticides [PDF]

Toxicological Sciences, 2013
Some clinicians assess the efficacy of pralidoxime in organophosphorus (OP) poisoned patients by measuring reactivation of butyrylcholinesterase (BuChE).
Nicholas Buckley, Michael Eddleston, Shaluka Jayamanne   +2 more
exaly   +2 more sources

Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine‐avizafone in healthy volunteers [PDF]

British Journal of Pharmacology, 2010
BACKGROUND AND PURPOSE Treatment of organophosphate poisoning with pralidoxime needs to be improved. Here we have studied the pharmacokinetics of pralidoxime after its intramuscular injection alone or in combination with avizafone and atropine using an ...
C. Abbara, Abbara, Chadi, Férec, Séverine, B. Diquet, I Bardot, J.M. Rousseau, B. Lelièvre, G. Lallement, S. Férec, B Diquet, Lelièvre, Bénédicte, S Ferec, Lallement, Guy, Rousseau, J.-M., Bardot, Isabelle, C Abbara, JM Rousseau, G Lallement, A Turcant, Diquet, Bertrand, A. Turcant, I. Bardot, Turcant, Alain, B Lelièvre   +23 more
exaly   +2 more sources

Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice [PDF]

NeuroToxicology, 2011
The organophosphorus (OP) pesticide malathion is a highly neurotoxic compound and its toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to cholinergic syndrome.
Dafré A L, Marcelo Farina, Kamil Kuca   +2 more
exaly   +2 more sources

Pharmacokinetics of pralidoxime chloride in the rat

Life Sciences, 1986
The pharmacokinetics of pralidoxime chloride (2-PAM) was studied in rats. Different groups of rats were given an intramuscular injection of 2-PAM at one of three doses (20, 40, or 80 mg/kg). This range of doses is used commonly in studies concerned with the efficacy of 2-PAM against poisoning by potent organophosphorus inhibitors of cholinesterase ...
M D, Green, B G, Talbot, C R, Clark
openaire   +2 more sources

Pralidoxime Safety andToxicity In Children

Prehospital Emergency Care, 2007
Currently, the safety of pralidoxime administration via adult autoinjectors for pediatric patients has not been established. Up until 2000, the published literature did not recommend its usage for children less than 12 kg or under the age of 10 years old.
Myles Thomas, Quail, Michael Wayne, Shannon   +1 more
openaire   +2 more sources

Pharmacokinetics of pralidoxime in Bubalus bubalis

British Veterinary Journal, 1988
Abstract Pharmacokinetics of pralidoxime (2-PAM) and its effect on blood enzymes were investigated in male buffalo calves following single intravenous administration (15 mg/kg). The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance were 0·086 ± 0·001 h, 2·36 ± 0·09 h, 1 ± 0·05 l/kg and 296 ± 13 ml/
A K, Srivastava, J K, Malik
openaire   +2 more sources

Use of palladium(II) chloride as colour-forming reagent in determination of pralidoxime chloride in water and tablets

Journal of Pharmaceutical and Biomedical Analysis, 1988
Pralidoxime chloride (PAM-2Cl) has been determined spectrophotometrically in Britton-Robinson buffer solution at pH = 6.45; the method is based on measurement of the absorbance of the Pd(II)-pralidoxime complex at 327 nm.
Binenfeld, Z.J., K. Karljiković-Rajic, Z. Binenfeld, Karljiković-Rajić, Katarina, Granov, A, B. Stanković, A. Granov, Stanković, B   +7 more
exaly   +2 more sources

Pralidoxime in the treatment of carbamate intoxication

The American Journal of Emergency Medicine, 1990
The use of oxime reactivators of inhibited cholinesterase enzymes in poisoning by carbamate compounds has received mixed reviews in the medical literature. Data are limited and inconsistent on the possible role oxime reactivators might have in carbamate intoxication. Based on existing experience, atropine remains the treatment of choice and pralidoxime
openaire   +2 more sources