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Effect of intravenous thiamine on pralidoxime kinetics
Clinical Pharmacology & Therapeutics, 1978Subjects were given pralidoxime chloride (5 mg/kg, intravenously) alone and again while they were receiving an infusion of thiamine hydrochloride. After the addition of thiamine: (1) overall, the urinary excretion of oxime was the same but the amount excreted in the first three hours was smaller; (2) the plasma half‐life of oxime lengthened; (3) the ...
J, Josselson, F R, Sidell
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Pralidoxime Chloride With Atropine in Dimpylate Poisoning
JAMA: The Journal of the American Medical Association, 1969To the Editor:— Pralidoxime (Protopam) chloride is a cholinesterase reactivator that has been recommended in the treatment of organic phosphate intoxications. Pralidoxime (2 PAM), however, is contraindicated in carbamate poisoning. It appears to be most effective when used in conjunction with atropine therapy.
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Pralidoxime hydrolysis of thiocholine esters.
Veterinary and human toxicology, 2003Pralidoxime (2-PAM) hydrolyzes both acetylthiocholine and butytylthiocholine in an apparent first-order manner, with higher rates observed at pH 8.0 compared to those at pH 7.4. When the reaction is followed by the decrease in pH due to hydrolysis, pralidoxime hydrolyzes acetylthiocholine but not acetylcholine or succinylcholine.
Richard G, Pannbacker +1 more
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