Results 161 to 170 of about 3,544 (200)
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Therapeutic Dosing of Pralidoxime Chloride
Drug Intelligence & Clinical Pharmacy, 1987Pralidoxime chloride is a useful agent in the treatment of organophosphate poisoning. Poisindex, a widely used poisoning treatment resource, recommends dosing pralidoxime chloride as an intermittent iv infusion every 8–12 hours, whereas other authors have used continuous iv infusion with good results.
D F, Thompson +3 more
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Sarin intoxication elevates plasma pralidoxime
Toxicology Letters, 1985Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication.
M D, Green, D E, Jones, D E, Hilmas
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Pralidoxime Safety andToxicity In Children
Prehospital Emergency Care, 2007Currently, the safety of pralidoxime administration via adult autoinjectors for pediatric patients has not been established. Up until 2000, the published literature did not recommend its usage for children less than 12 kg or under the age of 10 years old.
Myles Thomas, Quail +1 more
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Pharmacokinetics of pralidoxime in Bubalus bubalis
British Veterinary Journal, 1988Abstract Pharmacokinetics of pralidoxime (2-PAM) and its effect on blood enzymes were investigated in male buffalo calves following single intravenous administration (15 mg/kg). The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance were 0·086 ± 0·001 h, 2·36 ± 0·09 h, 1 ± 0·05 l/kg and 296 ± 13 ml/
A K, Srivastava, J K, Malik
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Pralidoxime in carbaryl poisoning: an animal model
Human & Experimental Toxicology, 2007Introduction: Poisoning from organophosphates and carbamates is a significant cause of morbidity and mortality worldwide. Concerns have been expressed over the safety and efficacy of the use of oximes such as pralidoxime (2-PAM) in patients with carbamate poisoning in general, and more so with carbaryl poisoning specifically.
Maria, Mercurio-Zappala +3 more
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Effect of intravenous thiamine on pralidoxime kinetics
Clinical Pharmacology & Therapeutics, 1978Subjects were given pralidoxime chloride (5 mg/kg, intravenously) alone and again while they were receiving an infusion of thiamine hydrochloride. After the addition of thiamine: (1) overall, the urinary excretion of oxime was the same but the amount excreted in the first three hours was smaller; (2) the plasma half‐life of oxime lengthened; (3) the ...
J, Josselson, F R, Sidell
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Pharmacokinetics of pralidoxime chloride in the rat
Life Sciences, 1986The pharmacokinetics of pralidoxime chloride (2-PAM) was studied in rats. Different groups of rats were given an intramuscular injection of 2-PAM at one of three doses (20, 40, or 80 mg/kg). This range of doses is used commonly in studies concerned with the efficacy of 2-PAM against poisoning by potent organophosphorus inhibitors of cholinesterase ...
M D, Green, B G, Talbot, C R, Clark
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Pralidoxime in the treatment of carbamate intoxication
The American Journal of Emergency Medicine, 1990The use of oxime reactivators of inhibited cholinesterase enzymes in poisoning by carbamate compounds has received mixed reviews in the medical literature. Data are limited and inconsistent on the possible role oxime reactivators might have in carbamate intoxication. Based on existing experience, atropine remains the treatment of choice and pralidoxime
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Pralidoxime Chloride With Atropine in Dimpylate Poisoning
JAMA: The Journal of the American Medical Association, 1969To the Editor:— Pralidoxime (Protopam) chloride is a cholinesterase reactivator that has been recommended in the treatment of organic phosphate intoxications. Pralidoxime (2 PAM), however, is contraindicated in carbamate poisoning. It appears to be most effective when used in conjunction with atropine therapy.
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