Results 51 to 60 of about 10,061 (158)

Drug–Drug Interaction Signals for Major Bleeding in Nursing Home Residents: High‐Throughput Screening of Clopidogrel and Oral Anticoagulants

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 8, August 2026.
ABSTRACT Purpose Nursing home (NH) residents are at high risk for major bleeding and are frequently exposed to complex medication regimens that may increase the likelihood of clinically important drug–drug interactions (DDIs). However, DDI evidence from community‐dwelling populations may not generalize to NH residents, and real‐world signals involving ...
Adam M. D'Amico, Melissa R. Riester, Charles E. Leonard, Daniel A. Harris, Lori A. Daiello, Yu‐Chia (Sam) Hsu, Douglas P. Kiel, Meghan A. Cupp, Kaleen N. Hayes, Andrew R. Zullo   +9 more
wiley   +1 more source

Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE‐ACS) Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundProton pump inhibitors (PPIs) reduce gastrointestinal bleeding events but may alter clopidogrel metabolism. We sought to understand the comparative effectiveness and safety of prasugrel versus clopidogrel in the context of proton pump inhibitor
Larry R. Jackson, Eric D. Peterson, Lisa A. McCoy, Christine Ju, Marjorie Zettler, Brian A. Baker, John C. Messenger, Douglas E. Faries, Mark B. Effron, David J. Cohen, Tracy Y. Wang   +10 more
doaj   +1 more source

P‐CAB vs. PPI for Upper Gastrointestinal Bleeding Prevention in Patients With Atherothrombotic Disease on Antithrombotic Therapy: A CDM Cohort Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 499-506, August 2026.
In patients with atherothrombotic disease on antithrombotic therapy, P‐CABs demonstrated a significantly superior protective effect against clinically significant upper GI haemorrhage compared to PPIs (aHR 0.22; p = 0.016). This real‐world study highlights P‐CABs as a more potent gastroprotective strategy for high‐risk populations requiring intensive ...
Min Joo Yoon, Soyoung Lee, Hye‐Kyung Jung, Min‐ho Kim, Suna Yu, Eui Sun Jeong, Chung Hyun Tae   +6 more
wiley   +1 more source

Prior Myocardial Infarction and Treatment Effect of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndromes ‐ A Post‐hoc Analysis of the ISAR‐REACT 5 Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The efficacy and safety of ticagrelor versus prasugrel in patients with acute coronary syndrome and prior myocardial infarction (MI) remain unstudied. We aimed to assess the treatment effect of ticagrelor versus prasugrel according to prior MI
Shqipdona Lahu, Maria Scalamogna, Gjin Ndrepepa, Maurizio Menichelli, Christian Valina, Rayyan Hemetsberger, Bernhard Witzenbichler, Isabell Bernlochner, Michael Joner, Erion Xhepa, Alexander Hapfelmeier, Sebastian Kufner, Hendrik B. Sager, Katharina Mayer, Thorsten Kessler, Karl‐Ludwig Laugwitz, Gert Richardt, Heribert Schunkert, Franz‐Josef Neumann, Adnan Kastrati, Salvatore Cassese   +20 more
doaj   +1 more source

Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea

Journal of Diabetes Investigation, Volume 17, Issue 8, Page 1367-1378, August 2026.
Among Korean adults with type 2 diabetes and no prior cardiovascular disease, thiazolidinedione use was associated with a lower risk of the primary composite outcome of stroke, myocardial infarction, hospitalization for heart failure, and all‐cause mortality compared to dipeptidyl peptidase‐4 inhibitor use. ABSTRACT Background Thiazolidinediones (TZDs)
Yun Young Choi, Jimin Jeon, Minyoul Baik, Joonsang Yoo, Jinkwon Kim   +4 more
wiley   +1 more source

A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI

Indian Heart Journal, 2015
Background: A thorough understanding of the patient's genotype and their functional response to a medication is necessary for improving event free survival.
P.C. Rath, Sundar Chidambaram, Pallavi Rath, Byomakesh Dikshit, Sudhir Naik, Prashant K. Sahoo, Brajraj Das, Mohanshankar Mahalingam, Lakshmipathi Khandrika, Jugnu Jain   +9 more
doaj   +1 more source

Influence of the Residual Gensini Score on Prognosis of Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, Volume 108, Issue 1, Page 76-83, July 1, 2026.
ABSTRACT Background The residual Gensini score (rGS) was developed to quantify the severity of coronary atheroma burden after coronary revascularisation. The predictive value of the rGS for clinical outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) remains unexplored.
Batric Popovic, Nassima Djaballah, Mirela Tomic, Renaud Fay, Victorine Fraichot, Florian Eggenspieler, Pierre Adrien Metzdorf, Jeanne Varlot, Edoardo Camenzind   +8 more
wiley   +1 more source

Feasibility and Safety of Distal Transradial Access in Patients With Out‐of‐Hospital Cardiac Arrest Undergoing Emergency PCI: A Single‐Center Retrospective Study

Catheterization and Cardiovascular Interventions, Volume 108, Issue 1, Page 269-274, July 1, 2026.
ABSTRACT Background Distal transradial access (dTRA) has gained attention for its lower risk of vascular complications compared to conventional transradial access (TRA). However, its feasibility and safety in patients with out‐of‐hospital cardiac arrest (OHCA) undergoing emergency percutaneous coronary intervention (PCI) remain uncertain.
Shiori Kawakami, Norimasa Taniguchi, Takeshi Yamada, Tetsuya Hata, Shunsuke Nakajima, Fumihiko Sano, Hideya Nakano, Mitusko Yokouchi, Aiko Ko, Akihiko Takahashi   +9 more
wiley   +1 more source

P2Y₁₂ Receptor Inhibitors in the Treatment of Patients with Acute Coronary Syndrome and Percutaneous Coronary Intervention: Possibilities of Prasugrel

Рациональная фармакотерапия в кардиологии, 2019
The possibilities of P2Y12 receptor inhibitors application in the treatment of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) are discussed in the article.
N. M. Vorobyeva
doaj   +1 more source

Spontaneous Coronary Reperfusion in STEMI After Pre‐Hospital Loading Dose of Triple Antithrombotic Therapy

Clinical Cardiology, Volume 49, Issue 7, July 2026.
ABSTRACT Background To evaluate the incidence and prognosis of spontaneous coronary reperfusion in STEMI using pre‐hospital loading dose of P2Y12 inhibitors. Methods This prospective bi‐centric study included STEMI patients who referred for primary PCI from June 1, to November 1, 2022.
Pierre Alain Meunier, Lea Juenin, Lionel Moulis, François Roubille, Pierre Robert, Jean Christophe Macia, Jean‐Michel Berdeu, Matthieu Steinecker, Benoit Lattuca, Laurent Schmutz, Luc Cornillet, Guillaume Cayla, Florence Leclercq   +12 more
wiley   +1 more source