Results 1 to 10 of about 755 (138)
Stability-Indicating LC Method for the Determination of Prasugrel Hydrochloride in Pharmaceutical Dosage Form [PDF]
Scientia Pharmaceutica, 2012 A simple, rapid and precise method was developed for the quantitative estimation of prasugrel hydrochloride in pharmaceutical dosage form. A chromatographic separation of prasugrel and its degradants was achieved with Zorbax XDB C(8), 150 × 4.6 mm, 3.5μm analytical column using aqueous solution of 0.05 M ammonium acetate pH 4.5 with acetic acid ...
Vinod K Ahirrao +2 more
exaly +6 more sources
Journal of Liquid Chromatography and Related Technologies, 2018 New high-performance liquid chromatography method was developed for the determination of prasugrel HCl-related substances. Impurity profile of prasugrel HCl was established by studying the degradation profile of it as an active pharmaceutical ingredient, for the first time, in the tablet form.
Sharif Arar, Kamal Sweidan
exaly +3 more sources
Acta Scientiarum. Health Sciences, 2014 Current study develops and validates a dissolution test for Prasugrel hydrochloride 10 mg in coated tablets. After sink condition, filters and drug stability were evaluated, the discriminatory dissolution conditions were achieved with a USP apparatus 1 ...
Camila Rigobello +2 more
doaj +2 more sources
Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride [PDF]
Open Pharmaceutical Sciences Journal, 2015 Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches.
Navjot Kanwar, Rakesh Kumar, V.R. Sinha
exaly +2 more sources
An Improvement to the Preparation of Prasugrel Hydrochloride
Journal of Chemical Research, 2013 An efficient synthesis of prasugrel, a thienopyridine ADP-receptor antagonists, is described. A thienopyridine inter-mediate was prepared by N-protection, boric acid substitution and N-substitution. After acid hydrolysis of the methyl ether and subsequent acetylation, prasugrel was obtained with a total yield of 50% after seven linear steps from 4,5,6 ...
Xianhua Pan
exaly +2 more sources
, 2019 ABSTRACT Objective: A simple, economic, selective and precise RP-HPLC method has been developed and validated for the estimation of related impurities of Aspirin and Prasugrel Hydrochloride in combined dosage form. Methods: A gradient reverse phase high performance liquid chromatography (RP-HPLC) analysis was performed on Hypersil BDS C18 column (250mm
Shweta A. Mishra a *, Dr. Ashlesha J. Chauhan b
openaire +3 more sources
Identification and Synthesis of Impurities Formed During Prasugrel Hydrochloride Preparation
Asian Journal of Chemistry, 2013 T. Umasankara Sastry +3 more
openaire +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Dual antiplatelet therapy after percutaneous coronary intervention reduces myocardial infarctions but increases bleeding. The risk of bleeding may be higher among Black patients for unknown reasons. Bleeding risk scores have not been validated
Brittain Heindl +11 more
doaj +1 more source
Low-Dose Prasugrel in Patients with Resistance to Clopidogrel for the Treatment of Cerebral Aneurysms [PDF]
Neurointervention, 2018 Thromboembolism is one of the major complications of stent assisted coiling in treatment of cerebral aneurysm. Clopidogrel resistance is so common and prasugrel is more effective in its rapid and potent effect.
Dongwhane Lee +4 more
doaj +1 more source
Clinical Case Reports, Volume 11, Issue 12, December 2023., 2023 Autopsy imaging (AI). (A) Plain CT shows massive pleural effusion (arrows) of 50 HU on AI, which implied that the fluid was blood. (B) After a few sets of chest compression, CT showed the contrast agent flow (arrow) from the cardiac cavity into the pericardium. AI, autopsy imaging; CT, computed tomography; HU, Hounsfield unit.
Kohei Aoe +4 more
wiley +1 more source