Results 1 to 10 of about 1,065 (142)
Stability-Indicating LC Method for the Determination of Prasugrel Hydrochloride in Pharmaceutical Dosage Form [PDF]
Scientia Pharmaceutica, 2012 A simple, rapid and precise method was developed for the quantitative estimation of prasugrel hydrochloride in pharmaceutical dosage form. A chromatographic separation of prasugrel and its degradants was achieved with Zorbax XDB C(8), 150 × 4.6 mm, 3.5μm analytical column using aqueous solution of 0.05 M ammonium acetate pH 4.5 with acetic acid ...
Vinod K Ahirrao, Rajendra P Pawar
exaly +5 more sources
Low-Dose Prasugrel in Patients with Resistance to Clopidogrel for the Treatment of Cerebral Aneurysms [PDF]
Neurointervention, 2018 Thromboembolism is one of the major complications of stent assisted coiling in treatment of cerebral aneurysm. Clopidogrel resistance is so common and prasugrel is more effective in its rapid and potent effect.
Dongwhane Lee +4 more
doaj +3 more sources
Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride [PDF]
Open Pharmaceutical Sciences Journal, 2015 Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches.
Navjot Kanwar, Rakesh Kumar, V.R. Sinha
exaly +2 more sources
An Improvement to the Preparation of Prasugrel Hydrochloride
Journal of Chemical Research, 2013 An efficient synthesis of prasugrel, a thienopyridine ADP-receptor antagonists, is described. A thienopyridine inter-mediate was prepared by N-protection, boric acid substitution and N-substitution. After acid hydrolysis of the methyl ether and subsequent acetylation, prasugrel was obtained with a total yield of 50% after seven linear steps from 4,5,6,
Xianhua Pan
exaly +2 more sources
Journal of Liquid Chromatography and Related Technologies, 2018 New high-performance liquid chromatography method was developed for the determination of prasugrel HCl-related substances. Impurity profile of prasugrel HCl was established by studying the degradation profile of it as an active pharmaceutical ingredient, for the first time, in the tablet form.
Sharif Arar, Kamal Sweidan
exaly +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Dual antiplatelet therapy after percutaneous coronary intervention reduces myocardial infarctions but increases bleeding. The risk of bleeding may be higher among Black patients for unknown reasons. Bleeding risk scores have not been validated
Brittain Heindl +11 more
doaj +1 more source
Newer agents in antiplatelet therapy: a review. [PDF]
, 2012 Antiplatelet therapy remains the mainstay in preventing aberrant platelet activation in pathophysiological conditions such as myocardial infarction, ischemia, and stroke.
Holinstat, Michael, Yeung, Jennifer
core +5 more sources
How to stop disproportionation of a hydrochloride salt of a very weakly basic compound in a non-clinical suspension formulation [PDF]
, 2021 Our objectives were to stabilize a non-clinical suspension for use in toxicological studies and to develop methods to investigate the stability of the formulation in terms of salt disproportionation.
Bansal, Indu +11 more
core +1 more source
Acta Scientiarum. Health Sciences, 2014 Current study develops and validates a dissolution test for Prasugrel hydrochloride 10 mg in coated tablets. After sink condition, filters and drug stability were evaluated, the discriminatory dissolution conditions were achieved with a USP apparatus 1 ...
Camila Rigobello +2 more
doaj +1 more source
Process validation of prasugrel hydrochloride tablet USP
International Journal of Pharmaceutical Chemistry and Analysis, 2020 Process validation is an essential part for the safety and quality of the drug products. Validation act as guidance that is intended to assist manufacturers in understanding quality management system requirements concerning process validation. It is a fundamental component for assuring the quality system used by pharmaceutical industries.
Yamuna Choudhary, Anju Goyal, Anju Goyal
openaire +2 more sources