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Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications
Chemistry – A European Journal, Volume 31, Issue 67, December 1, 2025.Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren +4 morewiley +1 more sourceThe Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman +206 morewiley +1 more source2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. [PDF]
, 2016 Peer ...Abreu Filho, Adriaan A. Voors, Anders Ahlsson, Antonio Coca, Antonis S. Manolis, Arsenault, Athanasios Manolis, Barbara Casadei, Bart Van Putte, Bogdan Alexandru Popescu, Bonizzi, Bronis, Bulent Gorenek, Clare J. Taylor, Clarkesmith, Cox, Cox, Dan Atar, Davy, de Salle, Dipak Kotecha, Dobromir Dobrev, Donna Fitzsimons, Emdin, Fabritz, Falk, Felmeden, Filip Casselman, Frank Ruschitzka, Friberg, Gerasimos Filippatos, Gerhard Hindricks, Goldberger, Goldstone, Gonzalo Baron Esquivias, Gregory Y. H. Lip, Gutierrez, Haemers, Hans-Christoph Diener, Hart, Hein Heidbuchel, Henry, Hou, Hughes, Irina Savelieva, Isabelle C. Van Gelder, Jensen, Jeroen Hendriks, John Camm, John McMurray, Jonas Oldgren, Jose Luis Zamorano, José M. Ferro, Juan Luis Tamargo, Karjalainen, Katja Zeppenfeld, Kobayashi, Lafuente-Lafuente, Lee, Lewis, Liakopoulos, Loose, Lundstrom, Magee, Manolis, Manuel Castella, Maxine Guenoun, McCabe, Nieuwlaat, Ott, Overvad, Paciaroni, Palareti, Panagiotis Vardas, Paulus Kirchhof, Pepine, Philippe Kolh, Piotr Ponikowski, Piotr Suwalski, Porter, Poulidakis, Raffaele De Caterina, Raphael Rosenhek, Roy, Sanjay Sharma, Savelieva, Scipione Carerj, Senechal, Spiridon Deftereos, Stacey, Stambler, Stefan Agewall, Stefan H. Hohnloser, Stefano Benussi, Stephan Windecker, Stroke Prevention in Atrial Fibrillation Investigators, Stroobandt, Szymanski, Tischenko, Tran, Tschuppert, Ulrich Schotten, Venteclef, Vijayalakshmi, Waldo, Wang, Watanabe, Werner Budts, Whitlock, Wilson +109 morecore +5 more sourcesAntiplatelet agents for the treatment of adults with COVID-19 [PDF]
, 2023 Background
Severe coronavirus disease 2019 (COVID‐19) can cause thrombotic events that lead to severe complications or death. Antiplatelet agents, such as acetylsalicylic acid, have been shown to effectively reduce thrombotic events in other diseases ...Andreas, Marike, Estcourt, Lise, Fischer, Anna-Lena, Martimbianco, Ana Luiza C, Messer, Sarah, Monsef, Ina, Pacheco, Rafael L, Riera, Rachel, Skoetz, Nicole, Stegemann, Miriam, Weibel, Stephanie +10 morecore +2 more sourcesPart 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the FDA Adverse Event Reporting System
Pharmacology Research &Perspectives, Volume 13, Issue 1, February 2025.ABSTRACT
The increasing utilization of cannabis products combined with lack of data regarding potential cannabis–prescription drug interactions is concerning. This study aimed to review published case reports and FDA Adverse Event Reporting System (FAERS) spontaneous reports to assess cannabis–drug interactions in persons aged 18 and over. A literature Maryann R. Chapin, Sandra L. Kane‐Gill, Xiaotong Li, Kojo Abanyie, Sanya B. Taneja, Susan Egbert, Mary F. Paine, Richard D. Boyce +7 morewiley +1 more source