Results 91 to 100 of about 19,502 (213)

Interaction Analysis using the Cambridge Structural Database – rapid access to intermolecular hydrogen‐bond frequencies and uses for coformer selection

Acta Crystallographica Section B, Volume 82, Issue 4, Page 391-398, August 2026.
We describe a coformer selection tool that uses knowledge of functional group interactions found in the Cambridge Structural Database to quickly identify complementary molecules to the target.A new methodology to perform virtual coformer screening, utilising data gathered on hydrogen‐bonding interactions present in the organic subset of the Cambridge ...
Joanna S. Stevens, Andrew G. P. Maloney, Elna Pidcock   +2 more
wiley   +1 more source

Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke Schistosoma mansoni.

PLoS Neglected Tropical Diseases
There are limited control measures for the disease schistosomiasis, despite the fact that infection with parasitic blood flukes affects hundreds of millions of people worldwide.
Clair R Henthorn, Paul McCusker, Winka Le Clec'h, Frédéric D Chevalier, Timothy J C Anderson, Mostafa Zamanian, John D Chan   +6 more
doaj   +1 more source

Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda

Parasites & Vectors, 2019
Background A key component of schistosomiasis control is mass drug administration with praziquantel. While control interventions have been successful in several endemic regions, mass drug administration has been less effective in others. Here we focus on
Christina L. Faust, Marco Crotti, Arinaitwe Moses, David Oguttu, Aidah Wamboko, Moses Adriko, Elizabeth K. Adekanle, Narcis Kabatereine, Edridah M. Tukahebwa, Alice J. Norton, Charlotte M. Gower, Joanne P. Webster, Poppy H. L. Lamberton   +12 more
doaj   +1 more source

Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1012-1027, August 2026.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source

Evaluation of the Subchronic Toxicity of the Complex Preparation for Dogs and Cats "Inspector Kvadro" for Cutaneous Use

Российский паразитологический журнал, 2019
The purpose of the research is to assess the subchronic toxicity of the complex drug for dogs and cats “Inspector Kvadro” for cutaneous use.Materials and methods.
I. A. Stepanova, V. V. Artemov, G. B. Arisova, I. P. Belykh   +3 more
doaj   +1 more source

Praziquantel [PDF]

Journal of Antimicrobial Chemotherapy, 1985
C P, Conlon, C J, Ellis
openaire   +2 more sources

Lower and upper boundaries for Praziquantel CAT-A.

, 2023
Lower and upper boundaries for Praziquantel CAT-A.
Elaine Xu (8149356), Ronny Priefer (2989251), Michael Rust (3051066), Christian Salmon (780906), Marcus Paoletti (15361112), Margaret Salmon (780905), Aliea Afnan (15361115)   +6 more
core   +1 more source

Barriers in the control of schistosomiasis with mass distribution of praziquantel in Bauchi State, Nigeria: a phenomenological study

Discover Health Systems
Background Schistosomiasis is a major public health problem in sub-Saharan Africa. Despite the World Health Organization’s recommendation for a widespread distribution of praziquantel, the prevalence of schistosomiasis continues to be alarmingly high ...
Sunday Charles Adeyemo, Obehi Oluwafemi Are-Daniel, Folasade Yetunde Adeleke, Eniola Dorcas Olabode, Abdulwaris Salisu Maleka, Odunlami Joseph Akintade, Ayodele Raphael Ajayi, Hussain Muhammad Abdulsalam, Rabiu Nafiu, Yunusa Usman   +9 more
doaj   +1 more source

The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)

, 2014
Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely distributed since 2006 through 'preventive chemotherapy' programmes to school-aged children or at-risk populations.
P. Delgado-Romero, Delgado-Romero, Petra, Keiser, Jennifer, J. Keiser, Olliaro, Piero, P. Olliaro   +5 more
core   +1 more source

Metabolic profiling of praziquantel enantiomers [PDF]

, 2014
Praziquantel (PZQ), prescribed as a racemic mixture, is the most readily available drug to treat schistosomiasis. In the present study, ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass ...
Idle, Jeffrey, Wang, Haina, Krausz, Kristopher W., Zhou, Kun, Gonzalez, Frank J., Zheng, Yang, Idle, Jeffrey R., Hu, Changyan, Sun, Dequn, Fang, Zhong-Ze, Zheng Y, Krausz KW, Wang H, Hu C, Sun D, Fang ZZ, Gonzalez FJ, Zhou K, Idle JR   +18 more
core   +1 more source