Results 101 to 110 of about 19,502 (213)

Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules

Pharmaceuticals, 2018
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently relies on a single drug, praziquantel, and despite its efficacy against the all schistosome species that parasitize humans, it displays some problematic drawbacks
Maria João Gouveia, Paul J. Brindley, Fátima Gärtner, José M. Correia da Costa, Nuno Vale   +4 more
doaj   +1 more source

Rare trematode infestation in irritable bowel syndrome: Pathogen or commensal?

Journal of Digestive Endoscopy, 2016
A healthy young adult male presented with complaints of frequent (>3/day) formed stools and passage of excessive mucous in stool for 3 months. He did not complain of nocturnal motions, recent diarrhea, blood in stool, straining, weight loss, or pain ...
Sunit K. Shukla, Pankaj K. Asati, Tuhina Banerjee, Vinod K. Dixit   +3 more
doaj   +1 more source

The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer) [PDF]

, 2017
Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely distributed since 2006 through ‘preventive chemotherapy' programmes to school-aged children or at-risk populations.
Delgado-Romero, Petra, Keiser, Jennifer, Olliaro, Piero   +2 more
core  

Parasitological cure rate of praziquantel treatment.

, 2018
Parasitological cure rate of praziquantel treatment.
Doris W. Njomo (298452), Murima Ng’ang’a (5866157), Jimmy H. Kihara (276570), Bridget W. Kimani (5866151), Amos K. Mbugua (5866154)   +4 more
core   +1 more source

Praziquantel

, 2010
Praziquantel-originally EMBAY 8440-was developed and subsequently marketed by Bayer as Biltricide (McMahon, 1981). It is a pyrazinoisoquinoline derivative, with the full chemical name of 2-cyclo-hexylcarbonyl-1,2,3,6,7,11bhexahydro- 4H-pyrazino[2,1-a] isoquinolin-4-one. Its molecular formula is CHNO and its molecular weight is 312.41.
openaire   +3 more sources

Effect of praziquantel treatment on antibody levels.

, 2019
Effect of praziquantel treatment on antibody levels.
Alison M. Elliott (114054), Rebecca N. Nsubuga (322027), Stephen C. Cose (6336221), Emily L. Webb (113996), Matthew Odongo (6336218), Robert Tweyongyere (473328), Swaib A. Lule (114005), Beatrice R. Nassanga (6336212), Allan Muhwezi (6336215)   +8 more
core   +1 more source

A qualitative assessment of community perceptions and practices towards schistosomiasis prior to introduction of a potential novel treatment option for preschool-age children in Kenya

Frontiers in Tropical Diseases
BackgroundOver 50 million preschool-age children (PSAC) in Africa need treatment for schistosomiasis but are excluded due to lack of a suitable child-friendly medication. The Paediatric Praziquantel Consortium has developed a novel paediatric formulation
Janet Masaku, Janet Masaku, John M. Gachohi, John M. Gachohi, John M. Gachohi, Alice Sinkeet, Mary Maghanga, Florence Wakesho, Wyckliff Omondi, Lisa Sophie Reigl, Isabelle L. Lange, Isabelle L. Lange, Andrea S. Winkler, Andrea S. Winkler, Andrea S. Winkler, Sammy M. Njenga, Mary Amuyunzu-Nyamongo   +16 more
doaj   +1 more source

The sites of action of praziquantel in a smooth muscle of Lymnaea stagnalis

, 1984
Praziquantel (1.6 × 10−6 M), a new anthelmintic drug, was shown to produce a sustained contracture in the penis retractor muscle of the freshwater snail Lymnaea stagnalis.
B. L. Brezden, D. R. Gardner
core   +1 more source

Baiting not-owned dogs against Echinococcus granulosus: innovative tools for integrated control

Parasitology
Cystic echinococcosis (CE), caused by the larval stage of the cestode Echinococcus granulosus, is one of the most widespread zoonoses in Mediterranean countries. Baiting not-owned dogs with praziquantel (PZQ), due to their key role in the maintaining the
Elena Ciccone, Antonio Bosco, Paola Pepe, Martina Nocerino, Nicola Lattero, Gerald Umhang, Laatamna AbdElkarim, Samia Lahmar, Yousra Said, Giorgio Saralli, Giuseppe Piegari, Maria Chiara Alterisio, Rania Baka, Smaragda Sotiraki, Franck Boué, Laura Rinaldi   +15 more
doaj   +1 more source

Effect of Praziquantel on Preventing Delayed Infection of Schistosoma japonicum in Buffaloes and Goats

Microorganisms
Schistosomiasis, caused by Schistosoma japonicum, continues to pose a major public health threat in East Asia, with an estimated 71 million people at risk of infection. Domestic animals, especially buffaloes and goats, serve as important reservoir hosts,
Xiang Gui, Bing Shao, Haoran Zhong, Rongxue Lv, Hao Li, Ke Lu, Yang Hong, Zhiqiang Fu, Zhenjie Lu, Mengge Xu, Yamei Jin, Jinming Liu   +11 more
doaj   +1 more source