Results 21 to 30 of about 37,525 (284)

Efficacy and Safety of Praziquantel for Treatment of Schistosoma mansoni Infection among School Children in Tanzania

Pathogens, 2019
Single-dose targeted praziquantel preventive chemotherapy is the WHO-recommended intervention for schistosomiasis control in endemic countries.
Rajabu Hussein Mnkugwe, Omary S. Minzi, Safari M. Kinung’hi, Appolinary A. Kamuhabwa, Eleni Aklillu   +4 more
doaj   +2 more sources

Effects of praziquantel on early life stages of Grass carp, <i>Ctenopharyngodon idella</i>. [PDF]

Vet Med (Praha)
This study aimed to assess the toxicity of the anthelmintic drug praziquantel in the early life stages of grass carp (Ctenopharyngodon idella). The toxicity was evaluated based on mortality, early ontogeny development, growth, oxidative stress biomarkers,
Velisek J, Strouhova A, Sandova M, Zuskova E, Dvorak P, Stara A.   +5 more
europepmc   +2 more sources

A review of the genetic determinants of praziquantel resistance in Schistosoma mansoni: Is praziquantel and intestinal schistosomiasis a perfect match?

Frontiers in Tropical Diseases, 2022
Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic trematodes belonging to the Schistosoma genus. The mainstay of schistosomiasis control is the delivery of a single dose of praziquantel (PZQ) through mass drug administration (MDA)
Shannan Summers, T. Bhattacharyya, F. Allan, J. R. Stothard, Andrew Edielu, B. Webster, M. Miles, A. Bustinduy   +7 more
semanticscholar   +1 more source

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance The drug praziquantel has been used for decades to treat infections caused by parasitic flatworms, including schistosomiasis which afflicts over 200 million people worldwide. Most flukes and tapeworms display high sensitivity to praziquantel;
C. Rohr, Daniel J Sprague, Sang-Kyu Park, Nicholas J Malcolm, J. Marchant   +4 more
semanticscholar   +1 more source

The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review

Journal of Tropical Medicine, 2022
Schistosomiasis remains a major global public health concern. Currently, the control of this neglected tropical disease still depends on chemotherapy to reduce the prevalence and intensity of the parasite infection.
X. Niu, Tao Hu, Yeonwoo Hong, Xiaoyan Li, Yu-min P Shen   +4 more
semanticscholar   +1 more source

Mechanism of praziquantel action at a parasitic flatworm ion channel

bioRxiv, 2021
Praziquantel (PZQ) is an essential medicine for treating parasitic flatworm infections such as schistosomiasis, which afflicts over 250 million people. However, PZQ is not universally effective, lacking activity against the liver fluke Fasciola.
Sang-Kyu Park, Lukas Friedrich, Nawal A Yahya, C. Rohr, E. Chulkov, David Maillard, F. Rippmann, T. Spangenberg, J. Marchant   +8 more
semanticscholar   +1 more source

Optimal single sampling time-point for monitoring of praziquantel exposure in children

Scientific Reports, 2021
Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in the target population. This study was aimed to investigate the optimal single sampling time-point
Rajabu Hussein Mnkugwe, Eliford Ngaimisi Kitabi, Safari Kinung’hi, Appolinary A. R. Kamuhabwa, Omary Mashiku Minzi, Eleni Aklillu   +5 more
doaj   +1 more source

Genetic analysis of praziquantel response in schistosome parasites implicates a Transient Receptor Potential channel

bioRxiv, 2021
Mass treatment with praziquantel (PZQ) monotherapy is the mainstay for schistosomiasis treatment. This drug shows imperfect cure rates in the field and parasites showing reduced PZQ response can be selected in the laboratory, but the extent of resistance
Winka Le Clec’h, Frédéric D. Chevalier, A. C. A. Mattos, Amanda Strickland, Robbie Diaz, Marina McDew-White, C. Rohr, S. Kinung’hi, F. Allan, B. Webster, J. Webster, A. Emery, D. Rollinson, A. G. Djirmay, Khalid M Al Mashikhi, Salem Al Yafae, M. A. Idris, H. Moné, G. Mouahid, P. LoVerde, J. Marchant, T. Anderson   +21 more
semanticscholar   +1 more source

Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations

Pharmaceutics, 2021
For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a neglected parasitic disease affecting more than 250 million people worldwide.
J. Boniatti, Patricija Januskaite, L. B. Fonseca, A. Viçosa, F. Amendoeira, C. Tuleu, A. Basit, A. Goyanes, M. Ré   +8 more
semanticscholar   +1 more source

Chromatographic Quantification of Ivermectin and Pranziquantel in the Tablets Using Stability Indicating RP-HPLC Method [PDF]

Pharmaceutical Sciences, 2019
Background: A new stability indicating RP-HPLC based assay method was developed to quantify ivermectin and praziquantel simultaneously and applied effectively to tablets.
Naga Venkata Suresh Kumar Devaka, Vallabhaneni Madhusudhan Rao   +1 more
doaj   +1 more source