Results 51 to 60 of about 37,525 (284)

Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models

Scientific Reports, 2020
Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established.
J. K. Nono, Kai Fu, Thabo Mpotje, Georgianna Varrone, N. Aziz, Paballo Mosala, Lerato Hlaka, S. Kamdem, Daigen Xu, T. Spangenberg, F. Brombacher   +10 more
semanticscholar   +1 more source

Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas [PDF]

, 2015
Background: Point-of-care (POC) tests for diagnosing schistosomiasis include tests based on circulating antigen detection and urine reagent strip tests.
Bossuyt, P.M.M., Gopalakrishna, G., Lamberton, P., Leeflang, M.M.G., Ochodo, E.A., Polman, K., Reitsma, J.B., Spek, B., van Lieshout, L.   +8 more
core   +3 more sources

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

Parasites & Vectors, 2011
Background Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s.
Zhao Qin-Ping, Guo Yi, Dong Hui-Fen, Liu Rong, Jiang Ming-Sen   +4 more
doaj   +1 more source

Misoprostol in the management of the third stage of labour in the home delivery setting in rural Gambia: a randomised controlled trial. [PDF]

, 2005
OBJECTIVE: To assess the effectiveness of 600 microg oral misoprostol on postpartum haemorrhage (PPH) and postpartum anaemia in a low income country home birth situation. DESIGN: Double blind randomised controlled trial.
Blum, Jennifer, Dampha, Yusupha, Morison, Linda, Sloan, Nancy, Sowe, Maimuna, Walraven, Gijs, Winikoff, Beverly   +6 more
core   +1 more source

Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study

Infectious Diseases of Poverty, 2017
Background Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis. A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence ...
Poppy H.L. Lamberton, Christina L. Faust, Joanne P. Webster   +2 more
doaj   +1 more source

Praziquantel is an effective drug for the treatment of Schistosoma Mansoni infection among school-aged children in Northwest Ethiopia

Tropical Medicine and Health, 2020
The appropriate drug for the treatment of schistosomiasis is praziquantel. However, low cure rate and existence of drug resistance both in vivo and in vitro were reported in different endemic areas.
Addisu Tesfie, Gebeyaw Getnet, Aberham Abere, G. Yihenew, Yerega Belete, Melkayehu Kassa, A. Gize   +6 more
semanticscholar   +1 more source

Resisting control of neglected tropical diseases: dilemmas in the mass treatment of schistosomiasis and soil-transmitted helminths in north-west Uganda [PDF]

, 2007
A strong case has recently been made by academics and policymakers to develop national programmes for the integrated control of Africa’s ‘neglected tropical diseases’.
Allen, Tim, Hastings, Julie, Parker, Melissa   +2 more
core   +1 more source

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Nature Communications, 2017
Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant   +11 more
doaj   +1 more source

Safety of topical administration of fluralaner plus moxidectin concurrently with praziquantel in cats

Parasites & Vectors, 2018
Background Fluralaner provides efficacy against feline ectoparasites following topical administration. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirofilaria immitis. Praziquantel is
Feli M. Walther, Petr Fisara, Rainer K. A. Roepke   +2 more
doaj   +1 more source

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel

Journal of Biological Chemistry, 2019
The anthelmintic drug praziquantel (PZQ) is used to treat schistosomiasis, a neglected tropical disease that affects over 200 million people worldwide.
Sang-Kyu Park, Gihan S. Gunaratne, E. Chulkov, Francie Moehring, P. McCusker, P. Dosa, John D. Chan, C. Stucky, J. Marchant   +8 more
semanticscholar   +1 more source