Results 31 to 40 of about 6,492 (168)

A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1.

PLoS ONE, 2022
Hypertension or hypotension prevails as a comorbidity in patients with heart failure (HF). Although blood pressure (BP) is an important factor in managing the mortality of HF, the molecular mechanisms of changes in BP have not been clearly understood in ...
Ji-One Kang, Tae Woong Ha, Hae-Un Jung, Ji Eun Lim, Bermseok Oh   +4 more
doaj   +1 more source

PRDM16 in Development and Disease [PDF]

Human Genetics & Embryology, 2014
PRDM16 is a member of the PRDM family of transcription co-regulators characterized by a PR domain (positive regulatory domain) that is similar to the SET domain found in lysine histone methyltransferases. Most PRDM proteins also contain one or more zinc finger domains that can confer direct DNA binding, in addition to other domains that mediate binding
openaire   +1 more source

PRDM16 (PR domain containing 16) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PRDM16 (PR domain containing 16), with data on DNA, on the protein encoded, and where the gene is implicated.
JL Huret, S Senon
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PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm

JCI Insight, 2023
Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening complications occur, predominantly involving aortic rupture. Currently, no drug-based treatments are available, primarily due to limited understanding of AAA pathogenesis. The
Zhenguo Wang, Xiangjie Zhao, Guizhen Zhao, Yanhong Guo, Haocheng Lu, Wenjuan Mu, Juan Zhong, Minerva Garcia-Barrio, Jifeng Zhang, Y. Eugene Chen, Lin Chang   +10 more
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MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundThe MDS1 and EVI1 complex locus (MECOM, also called PRDM3) and PR domain containing 16 (PRDM16) are two highly related zinc finger transcription factors associated with many malignancies. However, the mechanisms of MECOM and PRDM16 in prognosis
Meng Li, Meng Li, Hui Ren, Hui Ren, Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Na Liu, Meng Fan, Ke Wang, Tian Yang, Mingwei Chen, Puyu Shi   +12 more
doaj   +1 more source

PRDM16 controls a brown fat/skeletal muscle switch [PDF]

Nature, 2008
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage.
Patrick, Seale, Bryan, Bjork, Wenli, Yang, Shingo, Kajimura, Sherry, Chin, Shihuan, Kuang, Anthony, Scimè, Srikripa, Devarakonda, Heather M, Conroe, Hediye, Erdjument-Bromage, Paul, Tempst, Michael A, Rudnicki, David R, Beier, Bruce M, Spiegelman   +13 more
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PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression [PDF]

Cell Reports, 2017
How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear. Our previous studies suggest that PexRAP, a peroxisomal lipid synthetic enzyme, regulates PPARγ signaling and white adipogenesis.
Lodhi, Irfan J, Dean, John M, He, Anyuan, Park, Hongsuk, Tan, Min, Feng, Chu, Song, Haowei, Hsu, Fong-Fu, Semenkovich, Clay F   +8 more
openaire   +4 more sources

Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat

eLife, 2021
While beige adipocytes have been found to associate with dense sympathetic neurites in mouse inguinal subcutaneous white fat (iWAT), little is known about when and how this patterning is established.
Jingyi Chi, Zeran Lin, William Barr, Audrey Crane, Xiphias Ge Zhu, Paul Cohen   +5 more
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t(1;12)(p36;p13) ETV6/PRDM16 [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Review on t(1;12)(p36;p13) translocations, with data on clinics, and the genes involved.
Duhoux, Francois P, Poirel, Hélène A.
openaire   +2 more sources

Prdm16 Deficiency Leads to Age-Dependent Cardiac Hypertrophy, Adverse Remodeling, Mitochondrial Dysfunction, and Heart Failure

Cell Reports, 2020
Summary: Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response to physiological or pathological stress, prolonged hypertrophy can
Dasan Mary Cibi, Kathleen Wung Bi-Lin, Shamini Guna Shekeran, Reddemma Sandireddy, Nicole Tee, Anamika Singh, Yajun Wu, Dinesh Kumar Srinivasan, Jean-Paul Kovalik, Sujoy Ghosh, Patrick Seale, Manvendra K. Singh   +11 more
doaj   +1 more source