Results 21 to 30 of about 6,492 (168)
Developmental Dynamics, 2022 AbstractBackgroundPR domain containing 16 (PRDM16) is a key transcriptional regulator in the development of craniofacial, adipose, and neural tissues. Our lab identified PRDM16 expression in the epithelial cells of the Kölliker's organ (KO) that starts at ~E13.5 and is maintained until KO disappearance. A transgenic mouse model that carries a gene trap
Michael Ebeid +5 more
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Protein PRDM16 and its importance for adipose tissue (literature review)
Сибирский научный медицинский журнал, 2023 Currently, in Russia and in the world, there is an increase in the proportion of overweight and obese people among the population, which contributes to an increase in the number of socially significant diseases.
L. N. Afanaskina +3 more
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Prdm16 is required for normal palatogenesis in mice [PDF]
Human Molecular Genetics, 2009 Transcriptional cofactors are essential to the regulation of transforming growth factor beta (TGFbeta) superfamily signaling and play critical and widespread roles during embryonic development, including craniofacial development. We describe the cleft secondary palate 1 (csp1) N-ethyl-N-nitrosourea-induced mouse model of non-syndromic cleft palate ...
Bryan C, Bjork +4 more
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Frontiers in Pharmacology, 2022 Given that obesity and diabetes have been major public health concerns and that disease morbidities have been rising continuously, effective treatment for these diseases is urgently needed. Because adipose tissue metabolism is involved in the progression
Na Jiang +4 more
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Frontiers in Physiology, 2020 The dysregulated expression of microRNAs (miRs) has been associated with pathological and physiological processes of atherosclerosis (AS). In addition, PR domain-containing 16 (PRDM16), a transcriptional mediator of brown fat cell identity and smooth ...
Dongxing Liu +5 more
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Transcriptional Control of Brown Fat Determination by PRDM16 [PDF]
Cell Metabolism, 2007 Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells.
Seale, Patrick +8 more
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TSH promotes adiposity by inhibiting the browning of white fat
Adipocyte, 2020 Adiposity is caused by an imbalance between energy intake and consumption. Promotion of the browning of white fat increases energy expenditure and could combat adiposity.
Jianmei Zhang +6 more
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Российский кардиологический журнал, 2021 The article presents the examination of three generations of a family with diagnosed left ventricular noncompaction (LVNC) and various phenotypic manifestations of the disease (isolated, hypertrophic and dilated type of LVNC).
R. P. Myasnikov +23 more
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Prdm16 is a physiologic regulator of hematopoietic stem cells [PDF]
Blood, 2011 AbstractFetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute myeloblastic leukemias.
Aguilo, Francesca +8 more
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Influence without Presence: PRDM16 Casts Destiny [PDF]
Neuron, 2018 Chromatin modifications play an important role in cortical neurogenesis. In this issue, Baizabal et al. (2018) show how PRDM16, a histone methyltransferase, influences upper layer neuron production and migration by pre-setting enhancer activity within the developmental radial glial lineage.
Qing-Ran, Bai, Qin, Shen
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