Results 1 to 10 of about 6,492 (168)

Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte

Advanced Science, 2023
PRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood.
Shiting Zhao, Tao Nie, Lei Li, Qiaoyun Long, Ping Gu, Yuwei Zhang, Wei Sun, Zexin Lin, Qing Liu, Yue Qi, Wei Wang, Mengyuan Xie, Kerry Loomes, Chenleng Cai, Donghai Wu, Hannah Xiaoyan Hui   +15 more
doaj   +4 more sources

Adipocytes influence choroidal neovascularization via PRDM16 [PDF]

EMBO Molecular Medicine
Neovascular age-related macular degeneration (nAMD) is a prominent cause of blindness in the elderly, characterized by pathological subretinal choroidal neovascularization (CNV).
Roberto Diaz-Marin, Masayuki Hata, Vera Guber, Vincent De Guire, Ariel M Wilson, Sergio Crespo-Garcia, Przemyslaw Sapieha   +6 more
doaj   +3 more sources

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1 [PDF]

Advanced Science
Cellular senescence is a hallmark of aging and the accumulation of senescent cells (SnCs) accelerates the aging process, contributing to aging‐related organ disorders.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
doaj   +5 more sources

PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype [PDF]

Annals of Hematology
PRDM16 (PR Domain Containing 16) is a transcription factor that plays a critical role in hematopoietic stem cell maintenance. In acute myeloid leukemia (AML), PRDM16 overexpression is linked to specific cytogenetic risk groups and poor prognosis. However,
Sebastian Stasik, Jan-Niklas Eckardt, Christoph Röllig, Claudia D. Baldus, Hubert Serve, Carsten Müller-Tidow, Kerstin Schäfer-Eckart, Martin Kaufmann, Stefan W. Krause, Mathias Hänel, Andreas Neubauer, Gerhard Ehninger, Uwe Platzbecker, Martin Bornhäuser, Johannes Schetelig, Jan M. Middeke, Christian Thiede   +16 more
doaj   +2 more sources

PRDM16 protects retinal ganglion cells from ischemia-reperfusion Injury by regulating the RPL5/p53 axis [PDF]

Cellular and Molecular Life Sciences
Ischemia-reperfusion (I/R) injury represents a prevalent etiology of permanent vision loss across multiple ocular pathologies. Apoptotic death and inflammation of retinal ganglion cells (RGCs) induced by I/R injury constitutes a major contributor to ...
Yuqing Feng, Zhou Li, Jinfang Lu, Xujun Peng, Zijin He, Ao Jia, Yaohui Bao, Qiang Zheng, Xuan Xu, Yuxuan Ma, Chun Zou, Huiling Li, Dongshan Zhang   +12 more
doaj   +2 more sources

PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation [PDF]

eLife
BMP signaling acts as an instructive cue in various developmental processes such as tissue patterning, stem cell proliferation, and differentiation. However, it is not fully understood how this signaling pathway generates different cell-specific outputs.
Li He, Jiayu Wen, Qi Dai
doaj   +2 more sources

PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2/GPX4 axis

Redox Biology
Acute kidney injury (AKI) constitutes a significant public health issue. Sepsis accounts for over 50 % of AKI cases in the ICU. Recent findings from our research indicated that the PRD1-BF1-RIZ1 homeodomain protein 16 (PRDM16) inhibited the progression ...
Qiang Zheng, Jihong Xing, Xiaozhou Li, Xianming Tang, Dongshan Zhang   +4 more
doaj   +3 more sources

PRDM16 acts as a homeostasis regulation factor to suppress the transition of AKI to CKD via upregulation of eukaryotic initiation factor 6 [PDF]

Cellular and Molecular Life Sciences
Progressing from acute kidney injury (AKI) to chronic kidney disease (CKD) is acknowledged as a significant clinical challenge. Our recent works indicated that PR domain-containing 16 (PRDM16) impedes the progression of AKI and DKD.
Xiaozhou Li, Yang Xia, Xingjin Li, Yong Guo, Shuangfa Qiu, Huiling Li, Yijian Li, Lidong Wu, Dongshan Zhang   +8 more
doaj   +2 more sources

Directly targeting PRDM16 in thermogenic adipose tissue to treat obesity and its related metabolic diseases

Frontiers in Endocrinology
Obesity is increasing globally and is closely associated with a range of metabolic disorders, including metabolic associated fatty liver disease, diabetes, and cardiovascular diseases.
Liufeng Mao, Jinli Lu, Yunliang Hou, Tao Nie   +3 more
doaj   +3 more sources

Prdm16 regulates the postnatal fate of embryonic radial glia via Vcam1-dependent mechanisms [PDF]

Nature Communications
The mammalian brain undergoes rapid and extensive neurogenesis during the embryonic stage and limited neurogenesis during the adult stage, which results in ineffective repair of neural circuits in adults.
Jiwen Li, Marlesa I. Godoy, Yi Lu, Alice J. Zhang, Graciel Diamante, Elle Rathbun, Min Tian, In Sook Ahn, Arantxa Cebrian-Silla, Arturo Alvarez-Buylla, Xia Yang, Bennett G. Novitch, S. Thomas Carmichael, Ye Zhang   +13 more
doaj   +2 more sources