Results 11 to 20 of about 6,492 (168)
PRDM16 functions as a suppressor of lung adenocarcinoma metastasis
Journal of Experimental & Clinical Cancer Research, 2019 Background The transcription factor PR domain containing 16 (PRDM16) is known to play a significant role in the determination and function of brown and beige fat. However, the role of PRDM16 in tumor biology has not been well addressed.
Liang-Ru Fei +9 more
doaj +3 more sources
Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis [PDF]
Cell Reports, 2018 Summary: Transcriptional co-activator Prdm16 controls brown fat development and white fat browning, but how this thermogenic function is modulated post-translationally is poorly understood.
Qingbo Chen +4 more
doaj +4 more sources
PRDM16 regulates arterial development and vascular integrity
Frontiers in Physiology, 2023 Proper vascular formation is regulated by multiple signaling pathways. The vascular endothelial growth factor (VEGF) signaling promotes endothelial proliferation.
Michael Thompson +12 more
doaj +3 more sources
PRDM16 acts as a therapeutic downstream target of TGF-β signaling in chronic kidney disease [PDF]
JCI InsightTransforming growth factor β (TGF-β) signaling is the master modulator of renal fibrosis. However, targeting drugs have failed to prevent the progression of chronic kidney disease (CKD) in clinical trials due to the extensive biological regulation of TGF-
Qian Yuan +9 more
doaj +2 more sources
Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping [PDF]
Disease Models & Mechanisms, 2017 Gene trap mutagenesis is a powerful tool to create loss-of-function mutations in mice and other model organisms. Modifications of traditional gene trap cassettes, including addition of conditional features in the form of Flip-excision (FlEx) arrays to ...
Alexander Strassman +11 more
doaj +4 more sources
Prognostic impact of PRDM16 expression in acute myeloid leukemia with normal cytogenetics
Hematology, 2022 Purpose Cytogenetically normal acute myeloid leukemia (CN-AML) is a heterogeneous disease with variable clinical outcomes. The identification of potential biomarkers to better classify the patients with unfavorable prognoses who may require more ...
Xin Xiang +6 more
doaj +1 more source
PRDM16 co-operates with LHX2 to shape the human brain [PDF]
Oxford Open Neuroscience, 2023 Abstract PRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural stem cells. PRDM16 has been suggested to contribute to 1p36 deletion syndrome, one of the most prevalent subtelomeric microdeletion syndromes.
Varun Suresh +13 more
openaire +5 more sources
Frontiers in Cell and Developmental Biology, 2021 PRDM16 (known as MEL1), a member of the PR domain zinc finger family, has been implicated in multiple biological processes, including cancers. It is not clear yet whether PRDM16 is involved in tumor progress of papillary thyroid cancer (PTC).
Wan-Lin Liu +23 more
doaj +1 more source
PRDM16 expression in the developing mouse embryo [PDF]
Acta Histochemica, 2011 PRDM16 is a member of the PR domain-containing protein family and is associated with various disease states including myelodysplastic syndrome and adult T-cell leukemia, as well as developmental abnormalities such as cleft palate. It is also known to act as a regulator of cell differentiation. Expression analysis of PRDM16 is limited, especially within
Kristin H, Horn +3 more
openaire +2 more sources
Abnormal methylation of PRDM16 and PTPRN2 genes in chorionic villi in miscarriage
RUDN Journal of Medicine, 2023 Relevance. Abnormal epigenetic regulation of genes responsible for the development of the embryo and placenta is associated with many pregnancy pathologies. Aim. The aim of this work was to analyze the prevalence of abnormal methylation of the PRDM16 and
Stanislav A. Vasilyev +7 more
doaj +1 more source