Results 91 to 100 of about 92,448 (240)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Frequency of Pre-Analytical Errors and Its Causes in Glucose Specimen Collection: A Cross-Sectional Analysis in Bahawal Victoria Hospital, Pakistan

Pakistan Journal of Medicine and Dentistry
Background: The laboratory testing process comprises the pre-analytical, analytical, and post-analytical phases. The pre-analytical phase has the highest frequency of error among these three stages.
Hafiza Asma Hafiz, Muhammad Umair Naseer, Seemi Tanvir, Raima Kalhoro, Misbah Hafeez, Memona Zia   +5 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Benchmarking of pre-analytical non-conformities in the clinical pathology laboratory at hospital do câncer I / Benchmarking dos erros pré-analíticos no laboratório de patologia clínica do hospital do câncer I

Revista de Pesquisa Cuidado é Fundamental Online
Objetivo: rastrear os principais erros do processo da fase pré-analítica do Laboratório de Patologia Clínica e realizar um benchmarking com o estudo internacional coordenado pela IFCC (Federação Internacional de Química Clínica).
Raphael Gialluisi da Silva Ferreira, Alexandre Ribeiro Bello, EricaRipoll Hamer   +2 more
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

STUDY OF PRE ANALYTICAL ERRORS IN A MEDIUM SIZED PATHOLOGY LABORATORY

International Journal of Medical Laboratory Research, 2018
ABSTRACT: Introduction : Pre-analytical errors account for 49% to 68% of the errors in medical Laboratories, which can have a significant impact in patient care. Material and Methods: A retrospective analysis was performed on non conformance (NC) data over a 6 month period in a medium sized private Pathology Laboratory .
openaire   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Common Pre-Analytical Errors in a District Hospital Biochemistry Laboratory

TAJ: Journal of Teachers Association
Background: Pre-analytical laboratory errors significantly compromise diagnostic reliability, particularly in district hospitals where standardized specimen handling and quality monitoring remain inconsistent in routine laboratory practice. Objective: This study evaluates frequency, distribution, and determinants of common pre-analytical errors ...
null Sadia Thamin, Sharmin Akter, null Dilshad Jahan, null Jakia Jerin, null Most Rukhsana Khatun   +4 more
openaire   +1 more source