Results 91 to 100 of about 132,819 (274)

Pre-analytical workstations as a tool for reducing laboratory errors [PDF]

Journal of Medical Biochemistry, 2010
Reducing errors and improving quality are an integral part of Laboratory Medicine. Laboratory testing, a highly complex process commonly called the total testing process (TTP), is usually subdivided into three traditional (pre-, intra-, and post ...
Da Rin Giorgio
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A New Method for the Prevention of Pre-Analytical Errors due to Hemolysis: Intensive Training

, 2016
Conclusions: The IT method is effective in preventing hemolysis-induced pre-analytical ...
Ahmet Pekgor, Pekgor, Ahmet, Kadilar, Ozlem, Ozlem Kadilar, Yazar, Hayrullah, Yücel, Murat, Murat Yucel, Bozkurt, Berna, Berna Bozkurt, Hayrullah Yazar   +9 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

PRE-ANALYTICAL ERRORS AND PATIENT SAFETY PREANALITI^KE GRE[KE I BEZBEDNOST PACIJENATA [PDF]

, 2020
Summary: Laboratory medicine, as a specialty that had prioritised quality contr ol, has always been at the for efront of error reduction. In the last decades, a dramatic decr ease of analytical errors has been experienced, while a relatively high ...
Mario Plebani
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Pseudohyperkalemia Caused by EDTA Contamination: a Not Uncommon Pre-analytical Error

Siriraj Medical Journal, 2019
No ...
Sathima Laiwejpithaya, Sudarat Piyophirapong   +1 more
openaire   +5 more sources

Quality indicators of the pre-analytical phase [PDF]

Journal of Medical Biochemistry, 2012
Quality indicators are tools that allow the quantification of quality in each of the segments of health care in comparison with selected criteria. They can be defined as an objective measure used to assess the critical health care segments such as, for ...
Majkić-Singh Nada, Šumarac Zorica
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A Study of Pre-Analytical Errors in a Chemical Pathology Laboratory

Sokoto Journal of Medical Laboratory Science
No ...
Adepeju, Akinlawon Adetiloye, Ogunleke, Olumide Ayobami, Ibrahim , Ayisat Abiola, Adesiyan , Adekunle Abiodun, Onayade, Temitope O.   +4 more
openaire   +2 more sources