Results 101 to 110 of about 132,819 (274)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Kinematic Approach for 6-DOF Part Positioning

, 2013
Lien vers la version éditeur: http://link.springer.com/chapter/10.1007%2F978-3-642-30817-8_15This article proposes a fixturing system consists of a cuboid basep-late located through a 3-2-1 configuration of locators.
ANTOINE, Jean-François, MARTIN, Patrick, Patrick Martin, BUTT, Sajid-Ullah, Sajid Ullah Butt, Jean-Francois Antoine   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Errors : Detection and minimization in histopathology laboratories

Journal of Pathology of Nepal, 2015
The histopathological diagnosis plays a major role in the treatment of diseases. Errors in these reports affect patient care. Hence, it is of utmost importance for all practitioners of this specialty to be aware of possible errors in histopathology ...
S Karki
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Quality Assurance in Medical Laboratories in Developing Countries: Assessment of Pre-Analytical Errors in a Chemical Pathology Laboratory in a Tertiary Hospital in Nigeria

, 2020
BACKGROUND: The total testing process is made up of the pre-analytical, analytical and post analytical phases. Most of the non-conformities to laid down laboratory procedures are known to be at the pre-analytical phase, amounting to about 70% of errors ...
Ojule Aaron C., Allison Frederick Igila
core   +2 more sources

Types and frequency of laboratory errors in Sawanpracharak hospital, Nakornsawan province: One year after laboratory accreditation

Journal of Associated Medical Sciences, 2010
Since  laboratory  tests  provide  essential  information  for  physicians  to  make  medical  decisions  for diagnosis, treatment and monitoring of the patient’s condition, we evaluated the types and frequency of errors in our  in-patient  department ...
Pakasit Pratoomtone
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CHARACTERISTICS OF PRE-ANALYTICAL STAGE IN IMMUNOPHENOTYPING OF PERIPHERAL BLOOD CELLS

Медицинская иммунология, 2014
. Application of flow cytometry (FC) techniques has considerably expanded the opportunities for evaluation of immune cells, aiming for better diagnostics of immunodeficiency disorders, autoimmune and lymphoproliferative diseases, etc.A procedure of ...
L. V. Serebrovskaya, L. A. Ivanova, S. V. Khaidukov   +2 more
doaj   +1 more source