Results 81 to 90 of about 92,448 (240)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Pre-Analytical Laboratory Errors and Their Impact on Diagnostic Accuracy

International Journal of Computational and Experimental Science and Engineering
Pre-analytical laboratory errors refer to the mistakes that occur before the actual analysis of biological specimens, significantly impacting the overall accuracy of diagnostic testing. These errors can arise from various sources, including patient misidentification, improper collection techniques, inadequate specimen handling, and delays in ...
null Shuhrah Helal Hassan Alharthi, null Nawal MohAmmed Alhazmi, null Manal Mohammed Alhazmi, null Alenzi Bandar Saud K, null Nwrah Khaled Faleh Alsleman, null Nwrah Khaled Faleh Alsleman, null Ghalib Rakayan M Alenezi, null Wael Hassan Alrasasi, null Abdulrahman Eidhah Mohammed Al Malki, null Abdolrahman M N Alanze, null Jumah Ahmed Jaber Haqawi   +10 more
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Types and frequency of laboratory errors in Sawanpracharak hospital, Nakornsawan province: One year after laboratory accreditation

Journal of Associated Medical Sciences, 2010
Since  laboratory  tests  provide  essential  information  for  physicians  to  make  medical  decisions  for diagnosis, treatment and monitoring of the patient’s condition, we evaluated the types and frequency of errors in our  in-patient  department ...
Pakasit Pratoomtone
doaj  

CHARACTERISTICS OF PRE-ANALYTICAL STAGE IN IMMUNOPHENOTYPING OF PERIPHERAL BLOOD CELLS

Медицинская иммунология, 2014
. Application of flow cytometry (FC) techniques has considerably expanded the opportunities for evaluation of immune cells, aiming for better diagnostics of immunodeficiency disorders, autoimmune and lymphoproliferative diseases, etc.A procedure of ...
L. V. Serebrovskaya, L. A. Ivanova, S. V. Khaidukov   +2 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Evaluating the Completeness of Histopathology Sample Labeling [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان
Background and Aim: A major quality assurance target is minimizing error rates to enhance patient safety. Clinical laboratories have long focused their attention on quality control methods and quality assessment programs.
Fariba Abbasi Kokia, Nazila Ahmadi
doaj  

Does cleaning of venipuncture site with alcohol affect blood ethanol concentration?

Heliyon
Background: It is important to accurately determine the blood ethanol concentration (BEC) to ensure appropriate diagnosis and treatment of patients in the emergency department (ED) and protect their legal rights.
Deniz Kılıç, Adeviyye Aksoy, Ramazan Sivil, Taylan Kılıç, Ali Avcı, Mustafa Keşaplı, Güzin Aykal   +6 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source