Results 121 to 130 of about 132,819 (274)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Pre-analytical error for three point of care venous blood testing platforms in acute ambulatory settings: A mixed methods service evaluation

, 2020
IntroductionPoint of care blood testing to aid diagnosis is becoming increasingly common in acute ambulatory settings and enables timely investigation of a range of diagnostic markers.
GLOGOWSKA, Margaret, EDWARDS, George, HAYWARD, Gail, George Edwards, Thomas R Fanshawe, Jordan S. T. Bowen (8394231), Jordan S T Bowen, Steele, Rosie, Ian Smith (20961), Thomas R. Fanshawe (8394219), Bowen, Jordan, Rosie Steele, Ian Smith, Philip J. Turner (8394225), Caroline Croxson, Gail N. Hayward (8394234), Margaret Glogowska (3558125), Rosie Steele (8394228), George Edwards (8394222), Smith, Ian, Margaret Glogowska, Caroline Croxson (5245361), Philip J Turner, CROXSON, Caroline, Gail N Hayward, FANSHAWE, THOMAS, TURNER, Philip   +26 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Accruals, Investment and Errors-in-Variables [PDF]

We formulate well-known discretionary accruals models in an investment setting. Given that accruals basically consist of short-term investment, we introduce, (i) cash-flows, as a proxy for financial constraints and other financial markets imperfections ...
Francois Racicot, Christian Calmès, Denis Cormier, Raymond Théoret   +3 more
core  

Identification and reduction of pre-analytical errors in clinical chemistry through expert advice

Background: Diagnostics in Clinical chemistry laboratory is a pivotal part of clinical decision-making but is not exempt from ‘human errors’. Scientific innovations such as automation and electronic order test requesting have contributed to ...
Sholademi, Benjamin Ayoola, Benjamin Ayoola Sholademi   +1 more
core   +1 more source

Pre-Analytical Laboratory Errors and Their Impact on Diagnostic Accuracy

International Journal of Computational and Experimental Science and Engineering
Pre-analytical laboratory errors refer to the mistakes that occur before the actual analysis of biological specimens, significantly impacting the overall accuracy of diagnostic testing. These errors can arise from various sources, including patient misidentification, improper collection techniques, inadequate specimen handling, and delays in ...
null Shuhrah Helal Hassan Alharthi, null Nawal MohAmmed Alhazmi, null Manal Mohammed Alhazmi, null Alenzi Bandar Saud K, null Nwrah Khaled Faleh Alsleman, null Nwrah Khaled Faleh Alsleman, null Ghalib Rakayan M Alenezi, null Wael Hassan Alrasasi, null Abdulrahman Eidhah Mohammed Al Malki, null Abdolrahman M N Alanze, null Jumah Ahmed Jaber Haqawi   +10 more
openaire   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Benchmarking of pre-analytical non-conformities in the clinical pathology laboratory at hospital do câncer I / Benchmarking dos erros pré-analíticos no laboratório de patologia clínica do hospital do câncer I

Revista de Pesquisa Cuidado é Fundamental Online
Objetivo: rastrear os principais erros do processo da fase pré-analítica do Laboratório de Patologia Clínica e realizar um benchmarking com o estudo internacional coordenado pela IFCC (Federação Internacional de Química Clínica).
Raphael Gialluisi da Silva Ferreira, Alexandre Ribeiro Bello, EricaRipoll Hamer   +2 more
doaj  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

How to conduct External Quality Assessment Schemes for the pre-analytical phase?

, 2014
In laboratory medicine, several studies have described the most frequent errors in the different phases of the total testing process, and a large proportion of these errors occur in the pre-analytical phase.
Kristensen, Gunn B.B., Kristoffersen, Ann-Helen, Kristensen, Gunn Berit Berge, Kristoffersen, Ann Helen, Sverre Sandberg, Kristin Moberg Aakre, Ann Helen Kristoffersen, Moberg Aakre, Kristin, Sandberg, Sverre, Aakre, Kristin, Gunn B.B. Kristensen   +10 more
core   +1 more source