Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Post-fault operations of five-phase motor using a full-bridge inverter
, 2008 This paper compares the post-fault current control strategies of a five-phase permanent magnet motor adopting a half-bridge and a full-bridge converter. The analysis covers both the open circuit of one and two phases.
FORNASIERO, EMANUELE +7 more
core +1 more source
Pre-analytical issues in liquid biopsy – where do we stand?
Journal of Laboratory Medicine, 2020 It is well documented that in the chain from sample to the result in a clinical laboratory, the pre-analytical phase is the weakest and most vulnerable link. This also holds for the use and analysis of extracellular nucleic acids.
Fleischhacker Michael, Schmidt Bernd
doaj +1 more source
Analysis of Quality Indicators of the Pre-Analytical Phase on Blood Gas Analyzers, Point-Of-Care Analyzer in the Period of the COVID-19 Pandemic. [PDF]
Diagnostics (Basel), 2023 Brescia V +6 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Optimizing the pre-analytical phase for accurate HPV detection in skin disorders: insights from a cutaneous warts case study. [PDF]
Ther Adv Infect Dis, 2023 Redzic N +3 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Evaluation of the pre-analytical phase in parasitic morphology area, PNAEQ 2019 [PDF]
, 2020 Para garantir um diagnóstico clínico adequado, os procedimentos da fase pré-analítica não podem ser negligenciados. A implementação de um sistema de garantia da qualidade permite detetar, monitorizar, e reduzir ou eliminar os erros laboratoriais.
Viegas, Sílvia +8 more
core
Journal of High Institute of Public Health, 2011 Background: Nurses have a major role in caring for congenital hypothyroidism (CH) neonates in the pre-analytic phase of the Newborn Screening Program (NSP) as well as at the post-analytic phase.
Nagwa Y. Abou El-Enein, Omnia A. Nasar
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source