Results 141 to 150 of about 420,702 (297)
Pre-analytical phase - Portuguese EQAS (PNAEQ) since 2007 to 2014 [PDF]
, 2015 The National External Quality Assessment Program (PNAEQ) is included in the Department of Epidemiology of the National Health Institute Doutor Ricardo Jorge, Portugal.
Correia, Helena +3 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Evaluation of different needle gauge blood collection sets (23G/25G) in aged patients
Journal of Laboratory MedicineAged patients are often characterized by difficult blood sampling conditions. Smaller needle gauge (G) may be beneficial for venous access and reduced pain perception, however, potentially at the expense of lower blood quality for laboratory measurements.
Rosada Adrian +6 more
doaj +1 more source
Important quality indicators for the pre-analytical phase
Biochemia medica, 2012 Quality of a service or a product is a measure of the satisfaction of its consumers or customers. Quality of a healthcare service may thus be defined as a measure of its impact or effect on the patient care. Quality indicators are tools aimed to measure the quality of a health care service.
openaire +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Evaluating the Completeness of Histopathology Sample Labeling [PDF]
مجله علمی دانشگاه علوم پزشکی کردستانBackground and Aim: A major quality assurance target is minimizing error rates to enhance patient safety. Clinical laboratories have long focused their attention on quality control methods and quality assessment programs.
Fariba Abbasi Kokia, Nazila Ahmadi
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source