Results 131 to 140 of about 420,702 (297)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evaluation of the pre-analytical phase in parasitic morphology area, PNAEQ 2019 [PDF]

, 2020
Para garantir um diagnóstico clínico adequado, os procedimentos da fase pré-analítica não podem ser negligenciados. A implementação de um sistema de garantia da qualidade permite detetar, monitorizar, e reduzir ou eliminar os erros laboratoriais.
Viegas, Sílvia, Moutinho, Guilhermina, Costa, Quirina Santos, Jesus, Lúcia de, Ventura, Catarina, Fernandes, Teresa Baptista, Faria, Ana, Júlio, Cláudia, Cardoso, Ana   +8 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effect of blood collection tube variability on biochemistry test reliability: focus on possible contamination and other discrepancies

Türk Biyokimya Dergisi
The aim of this study was to evaluate the effects of five different brands of gel separator biochemistry serum tubes (BD-Vacutainer, Greiner Bio One-Vacuette, Samplix, Pirmax and Ayset) on routine biochemistry test measurement results performed with both
Balci Tevfik, Ayan Durmuş, Zeybek Aydoğan Kader, Küçükkaya Onur, Demirtaş Ayşe, Özdemir Muammer, Bayram Ergül, Bayraktar Bariş   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Some remarks on stability for a phase-field model with memory [PDF]

, 2006
The phase field system with memory can be viewed as a phenomenological extension of the classical phase equations in which memory effects have been taken into account in both fields.
Novick-Cohen, A., Grinfeld, M.
core  

Ethical conflicts in the pre-analytical phase in clinical analyzes [PDF]

Professional who works in the health area must acquire the necessary knowledge about ethics to provide the patient with confidence, security and optimal work.
Tenesaca Serpa, Andrea, Arteaga Sarmiento, Sandra, Pacheco Moscoso, Gabriela, Andrade Campoverde, Diego   +3 more
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Factors associated with non-compliance to the pre-analytical phase of the malaria thick blood smear in the Lemba Health Zone, Democratic Republic of Congo

Journal of Interventional Epidemiology and Public Health
Introduction: The medical laboratory is an important link in the process of patient care; it guides the practitioner to make a diagnosis or prognosis of diseases, especially to ensure therapeutic follow-up.
Fidele Djamba Okitokonda, Ernest Ombha Loshima, Guy Bilulu Suama, Freddy Kambale Kavoga, Eric Panzi Kalunda, Pélagie Babakazo Diambulula   +5 more
doaj   +1 more source