Results 131 to 140 of about 9,210,402 (249)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Pre-analytical (mis)handling of plasma investigated by 1H-NMR metabolomics [PDF]
The pre-analytical handling of plasma, how it is drawn, processed, and stored, influences its composition. Samples in e.g. biobanks often lack this information and consequently important information about their quality.
Linda, Paulson +5 more
core +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Evaluating the Completeness of Histopathology Sample Labeling [PDF]
مجله علمی دانشگاه علوم پزشکی کردستانBackground and Aim: A major quality assurance target is minimizing error rates to enhance patient safety. Clinical laboratories have long focused their attention on quality control methods and quality assessment programs.
Fariba Abbasi Kokia, Nazila Ahmadi
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Development of superparamagnetic particles for analytical pre-concentration
The very low levels of trace heavy metals and organic pollutants in water can present difficulties for the analytical chemist that can often be overcome by employing a pre-concentration method to enrich the analyte.
Vescovo, Luca
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pre-Analytical Phase in Parasitic Morphology
, 2020 Monografia e relatório de estágio do Mestrado em Análises Clínicas, apresentado à Faculdade de Farmácia da Universidade de Lisboa, 2020.Prova defendida a 30/10/2020.O mestrado em Análises Clínicas integra no plano curricular um estágio laboratorial que ...
Jesus, Lúcia Margarida Coelho de
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source