Results 121 to 130 of about 420,702 (297)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Analysis and design of Fault-Tolerant drives [PDF]
, 2008 The field of fault-tolerant applications is surely among the most exciting and potentially innovative modern research of the electrical motor where the design is freedom and new solution can be explored.
Dai Pre, Michele
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Advances in Laboratory MedicineQuality indicators (QIs) are a valuable tool for monitoring and improving extra-analytical phase performance in the clinical laboratory (CL). For that reason, the Spanish Society of Laboratory Medicine (SEQCML) launched its Pre-analytical Phase EQA ...
Caballero Garralda Andrea +11 more
doaj +1 more source
Development of superparamagnetic particles for analytical pre-concentration [PDF]
The very low levels of trace heavy metals and organic pollutants in water can present difficulties for the analytical chemist that can often be overcome by employing a pre-concentration method to enrich the analyte.
Vescovo, Luca
core
Final Report from the Primary phase: pre-school, school and family influences on children’s development during Key Stage 2 (7-11) [PDF]
, 2008 The Effective Pre-school and Primary Education project (EPPE 3-11) is Europe’s largest longitudinal study, which uses multi-level modelling to investigate the effects of pre-school and primary education on pupils’ developmental outcomes.
Sammons, Pamela +10 more
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