Results 81 to 90 of about 226,792 (352)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Polarization: A Method to Reveal the True Nature of the Dusty S-Cluster Object (DSO/G2)

Galaxies, 2018
There have been different scenarios describing the nature of a dusty source, noted as Dusty S-cluster Object (DSO) or G2, orbiting around the Galactic centre super-massive black hole.
Banafsheh Shahzamanian, Andreas Eckart, Michal Zajacek, Monica Valencia-S., Nadeen B. Sabha   +4 more
doaj   +1 more source

Molecular Mapping of DR Tau’s Protoplanetary Disk, Envelope, Outflow, and Large-scale Spiral Arm

The Astrophysical Journal, 2023
DR Tau has been noted for its unusually high variability in comparison with other T Tauri stars. Although it is one of the most extensively studied pre-main-sequence stars, observations with millimeter interferometry have so far been relatively limited ...
Jane Huang, Edwin A. Bergin, Jaehan Bae, Myriam Benisty, Sean M. Andrews   +4 more
doaj   +1 more source

Circumstellar Material Associated with Solar-Type Pre-Main-Sequence Stars: A Possible Constraint on the Timescale for Planet Building

, 1989
The observed frequency distribution of near-IR excesses for a sample of 83 stars in the Taurus-Auriga star-forming complex is used to provide an estimate of the number of solar-type premain-sequence (PMS) stars surrounded by circumstellar disks.
K. Strom, S. Strom, S. Edwards, S. Cabrit, M. Skrutskie   +4 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Revisiting Hipparcos data for pre-main sequence stars [PDF]

, 1999
We cross-correlate the Herbig & Bell and Hipparcos Catalogues in order to extract the results for young stellar objects (YSOs). We compare the distances of individual young stars and the distance of their presumably associated molecular clouds, taking into account post-Hipparcos distances to the relevant associations and using Hipparcos ...
Bertout, C., Robichon, N., Arenou, Frédéric   +2 more
openaire   +4 more sources

The pre-main-sequence star IP Persei [PDF]

Astronomy & Astrophysics, 2001
We present the results of high- and low-resolution spectroscopic and broadband multicolour photometric observations of the emission-line A-type star IP Per. Significant variations of the Balmer line profiles and near-IR brightness are detected.
E. L. Chentsov, E. L. Chentsov, V. G. Klochkova, V. G. Klochkova, Pedro García-Lario, Anatoly S. Miroshnichenko, Anatoly S. Miroshnichenko, Richard O. Gray, J. V. Perea Calderón, Karen S. Bjorkman   +9 more
openaire   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

An Eccentric Binary with a Misaligned Circumbinary Disk

The Astrophysical Journal Letters
We present spectroscopic and photometric observations of Bernhard-2, which was previously identified as a candidate system that hosts a misaligned circumbinary disk. Our spectroscopic measurements confirm that Bernhard-2 indeed contains an eccentric ( e =
Zhecheng Hu, Wei Zhu, Fei Dai, Ping Chen, Yang Huang, Min Fang, Richard S. Post   +6 more
doaj   +1 more source