Results 91 to 100 of about 270,676 (398)
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Identification of Nuclear and Cytoplasmic mRNA Targets for the Shuttling Protein SF2/ASF [PDF]
, 2008 The serine and arginine-rich protein family (SR proteins) are highly conserved regulators of pre-mRNA splicing. SF2/ASF, a prototype member of the SR protein family, is a multifunctional RNA binding protein with roles in pre-mRNA splicing, mRNA export ...
Caceres, Javier F +5 more
core +5 more sources
A cyclophilin functions in pre-mRNA splicing [PDF]
The EMBO Journal, 2002 We report that the cyclophilin USA-CyP is part of distinct complexes with two spliceosomal proteins and is involved in both steps of pre-mRNA splicing. The splicing factors hPrp18 and hPrp4 have a short region of homology that defines a high affinity binding site for USA-CyP in each protein.
Tom Misteli +3 more
openaire +3 more sources
FEBS Open Bio, EarlyView.In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna +4 more
wiley +1 more source
Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. [PDF]
PLoS ONE, 2007 Serine/arginine-rich (SR) proteins are essential splicing factors with one or two RNA-recognition motifs (RRMs) and a C-terminal arginine- and serine-rich (RS) domain. SR proteins bind to exonic splicing enhancers via their RRM(s), and from this position
Stephanie D Shaw +3 more
doaj +1 more source
Kinetic Competition During the Transcription Cycle Results in Stochastic RNA Processing [PDF]
, 2014 Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic processes, including initiation, elongation, splicing, and cleavage. Kinetic competition between these processes has been proposed to determine RNA fate, yet such coupling ...
Chow, Carson C. +5 more
core +3 more sources
An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity
Nature Communications, 2017 The process of RNA splicing influences many physiological processes, including plant immunity. However, how plant parasites manipulate host RNA splicing process remains unknown. Here we demonstrate that PsAvr3c, an avirulence effector from oomycete plant
Jie Huang +17 more
semanticscholar +1 more source
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Splicing-coupled 3' end formation requires a terminal splice acceptor site, but not intron excision [PDF]
, 2012 Splicing of human pre-mRNA is reciprocally coupled to 3′ end formation by terminal exon definition, which occurs co-transcriptionally. It is required for the final maturation of most human pre-mRNAs and is therefore important to understand.
Davidson, L., West, S.
core +3 more sources
Pre-mRNA splicing is a determinant of nucleosome organization [PDF]
Epigenetics & Chromatin, 2013 Chromatin organization affects alternative splicing and previous studies have shown that exons have increased nucleosome occupancy compared with their flanking introns. To determine whether alternative splicing affects chromatin organization we developed a system in which the alternative splicing pattern switched from inclusion to skipping as a ...
Gil Ast +2 more
openaire +5 more sources