Results 71 to 80 of about 205,219 (310)
α-Globin pre-mRNA splicing, revisited [PDF]
Blood, 2019 In this issue of Blood, Ji et al have identified a novel regulatory mechanism that ensures proper splicing of human α-globin pre-messenger RNA (pre-mRNA).
openaire +2 more sources
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
Cell Reports, 2019 Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation.
Kelsi O. West +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements [PDF]
, 1999 We report striking differences in the substrate specificities of two human SR proteins, SP2/ASF and SC35, in constitutive splicing. beta-Globin pre-mRNA (exons 1 and 2) is spliced indiscriminately with either SR protein.
Mayeda, A. +4 more
core +1 more source
A coactivator of pre-mRNA splicing [PDF]
Genes & Development, 1998 The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD). SRm160 contains multiple SR repeats, but unlike proteins of the SR family of splicing factors, lacks an RNA recognition motif ...
B J, Blencowe +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing
iScience, 2019 Summary: Understanding endogenous regulation of stress resistance and homeostasis maintenance is critical to developing neuroprotective therapies. Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved essential enzyme that confers ...
Joun Park +6 more
doaj +1 more source
Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF. [PDF]
PLoS ONE, 2008 Alternative splicing of transcripts in a signal-dependent manner has emerged as an important concept to ensure appropriate expression of splice variants under different conditions.
Anne Tisserant, Harald König
doaj +1 more source
Saturation mutagenesis reveals manifold determinants of exon definition. [PDF]
, 2017 To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene.
Anquetil, Vincent +9 more
core +2 more sources