Results 51 to 60 of about 127,514 (315)

Operon conservation and the evolution of trans-splicing in the phylum Nematoda [PDF]

, 2006
The nematode Caenorhabditis elegans is unique among model animals in that many of its genes are cotranscribed as polycistronic pre-mRNAs from operons.
Mark L Blaxter, Blaxter, Mark L, Blaxter Mark L, David B Guiliano, Guiliano David B, Guiliano, David B   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Supraspliceosome — A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus

Computational and Structural Biotechnology Journal, 2014
Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21 MDa) and highly dynamic RNP machine — the supraspliceosome.
Kinneret Shefer, Joseph Sperling, Ruth Sperling   +2 more
doaj   +1 more source

Principles and correction of 5’-splice site selection

RNA Biology, 2022
In Eukarya, immature mRNA transcripts (pre-mRNA) often contain coding sequences, or exons, interleaved by non-coding sequences, or introns. Introns are removed upon splicing, and further regulation of the retained exons leads to alternatively spliced ...
Florian Malard, Cameron D Mackereth, Sébastien Campagne   +2 more
doaj   +1 more source

The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation [PDF]

, 2003
Cleavage and polyadenylation factor (CPF) is a multi-protein complex that functions in pre-mRNA 3'-end formation and in the RNA polymerase II (RNAP II) transcription cycle.
Sadowski, Martin, Kyburz, A., Kyburz, Andrea, Dichtl, B., Keller, W., Keller, Walter, Sadowski, M., Dichtl, Bernhard   +7 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Functional coordination of alternative splicing in the mammalian central nervous system [PDF]

, 2007
BACKGROUND: Alternative splicing (AS) functions to expand proteomic complexity and plays numerous important roles in gene regulation. However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known.
Saltzman, A.L., Rozenhek, A., Christine Misquitta, Ofer Shai, Frey, B.J., Blencowe, B.J., Babak, T., Aviad Rozenhek, Misquitta, C., Mohammad, N., Zhang, W., Brendan J Frey, Lee, L., Arneet L Saltzman, Timothy R Hughes, Willaime-Morawek, S., Qun Pan, Leo Lee, Derek van der Kooy, Barash, Y., Wen Zhang, Yoseph Barash, Joanna Y Ip, Benjamin J Blencowe, Pan, Q., Matthew Fagnani, Sandrine Willaime-Morawek, van der Kooy, D., Naveed Mohammad, Fagnani, M., Shai, O., Hughes, T.R., Tomas Babak   +32 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Functional characterization of Ysh1p, the yeast endonuclease involved in 3" end processing and in transcription termination of RNA polymerase II transcripts [PDF]

, 2008
Eukaryotic RNA polymerase II (RNAP II) is involved in the synthesis of two major classes of transcripts: messenger RNAs (mRNAs) and small nuclear and small nucleolar RNAs.
Garas, Monika
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source