Results 61 to 70 of about 127,514 (315)

Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. [PDF]

, 1997
Published ...
Cáceres, J. F., Misteli, T, Spector, DL, Javier F. Cáceres, Cáceres, JF, Krainer, AR, Screaton, G. R., Spector, D. L., Tom Misteli, Adrian R. Krainer, Krainer, A. R., Gavin R. Screaton, Screaton, GR, David L. Spector, Misteli, T.   +14 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development of an in vitro pre-mRNA splicing assay using plant nuclear extract

Plant Methods, 2018
Background Pre-mRNA splicing is an essential post-transcriptional process in all eukaryotes. In vitro splicing systems using nuclear or cytoplasmic extracts from mammalian cells, yeast, and Drosophila have provided a wealth of mechanistic insights into ...
Mohammed Albaqami, Anireddy S. N. Reddy
doaj   +1 more source

Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. [PDF]

PLoS Genetics, 2014
The steroid hormone ecdysone coordinates insect growth and development, directing the major postembryonic transition of forms, metamorphosis. The steroid-deficient ecdysoneless1 (ecd1) strain of Drosophila melanogaster has long served to assess the ...
Ann-Katrin Claudius, Patrizia Romani, Tobias Lamkemeyer, Marek Jindra, Mirka Uhlirova   +4 more
doaj   +1 more source

Pre‐mRNA splicing modulations in senescence [PDF]

Aging Cell, 2002
SummaryAging and associated diseases involve multilevel changes in the complex phenomenon of alternative splicing. Here, we review the potential genomic and environmental origins of such changes and discuss the research implications of these findings.
Eran, Meshorer, Hermona, Soreq
openaire   +2 more sources

Biochemical characterization and three-dimensional structure analysis of the yeast cleavage and polyadenylation factor CPF [PDF]

, 2008
In eukaryotes, protein-encoding genes are transcribed in the nucleus by RNA polymerase II (RNAP II). Before the gene transcript (pre-mRNA) is transported to the cytoplasm and can function in translation, it has to undergo three specific maturation ...
Paguet, Bertrand
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages

Cell Reports, 2019
Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation.
Kelsi O. West, Haley M. Scott, Sylvia Torres-Odio, A. Phillip West, Kristin L. Patrick, Robert O. Watson   +5 more
doaj   +1 more source

Minigene splicing assays reveal new insights into exonic variants of the SLC12A3 gene in Gitelman syndrome

Molecular Genetics & Genomic Medicine, 2023
Background Gitelman syndrome (GS) is a type of salt‐losing tubular disease, most of which is caused by SLC12A3 gene variants, and missense variants account for the majority.
Xiaomeng Shi, Hong Wang, Ruixiao Zhang, Zhiying Liu, Wencong Guo, Sai Wang, Xuyan Liu, Yanhua Lang, Irene Bottillo, Bingzi Dong, Leping Shao   +10 more
doaj   +1 more source

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

, 2005
We have isolated the human protein SNEV as downregulated in replicatively senescent cells. Sequence homology to the yeast splicing factor Prp19 suggested that SNEV might be the orthologue of Prp19 and therefore might also be involved in pre-mRNA splicing.
Grillari, Johannes, Lamond, Angus I., Stadler, Guido, Voglauer, Regina, Eisenhaber, Frank, Löscher, Marlies, Lamond, Angus I.; id_orcid, Pokar, Marion, Ajuh, Paul, Grey, Martin, Fortschegger, Klaus, Ernst, Wolfgang, Katinger, Hermann, Chusainow, Janet   +13 more
core   +1 more source