Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy [PDF]
, 2012 This work was funded by the Wellcome Trust (grant ID WT078810MA)It is becoming increasingly clear that defects in RNA metabolism can lead to disease. Spinal muscular atrophy (SMA), a leading genetic cause of infant mortality, results from insufficient ...
Clelland, Allyson Kara +2 more
core +1 more source
Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns.
PLoS Biology, 2006 RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymerase ...
Martin J Hicks +3 more
doaj +1 more source
Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. [PDF]
PLoS ONE, 2011 We have previously identified an Alu-derived Intronic Splicing enhancer (ISE) in the Ataxia Teleangectasia Mutated gene (ATM) that facilitates intron pre-mRNA processing and leads to the inclusion of a cryptic exon in the final mRNA transcript.
Tibor Pastor, Franco Pagani
doaj +1 more source
Regulation of age-dependent expression patterns of five transcription factors in Larix kaempferi
Forestry Research, 2023 To reveal the regulatory mechanisms underlying age-dependent expression patterns, we characterized seven age-related genes, LaDAL1, LaAGL2-2, LaAGL2-3, LaAGL11, LaSOC1-1, LaAP2-1, and LaAP2-2 in terms of transcription and intron splicing in Larix ...
Xiangyi Li +4 more
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Pre-mRNA Splicing in the Nuclear Landscape [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2019 Eukaryotic gene expression requires the cumulative activity of multiple molecular machines to synthesize and process newly transcribed pre-messenger RNA. Introns, the noncoding regions in pre-mRNA, must be removed by the spliceosome, which assembles on the pre-mRNA as it is transcribed by RNA polymerase II (Pol II).
Carrocci, Tucker J. +1 more
openaire +2 more sources
A trio of unique alternative splicing patterns : the splicing of tandem NAGNAG acceptors, transcription-start-site-dependent and mutually dependent cassette exons [PDF]
, 2008 With the rapid increase in the volume of genomic and transcript data in mouse and human, a diverse set of alternative splicing patterns can be discovered.
Chern, Tzu-Ming
core +1 more source
A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T +3 more
core +1 more source
Electron tomography reveals posttranscriptional binding of pre-mRNPs to specific fibers in the nucleoplasm [PDF]
, 2000 International audienceUsing electron tomography, we have analyzed whether the Balbiani ring (BR) pre-mRNP particles in transit from the gene to the nuclear pore complex (NPC) are bound to any structure that could impair free diffusion through the ...
Sabri, N +20 more
core +1 more source
PLoS ONE, 2020 Pre-mRNA splicing is critical for achieving required amounts of a transcript at a given time and for regulating production of encoded protein. A given pre-mRNA may be spliced in many ways, or not at all, giving rise to multiple gene products.
Hsin-Hao T Hsiao +5 more
doaj +1 more source
Neurotrauma Reports, 2022 To determine molecular changes that correlate with long-term physiological changes after spinal cord injury associated with spasticity, we used a complete transection model with an injury at sacral spinal level S2, wherein tail spasms develop in rats ...
Samantha N. Hart +9 more
doaj +1 more source