Results 41 to 50 of about 205,219 (310)
Understanding pre-mRNA splicing through crystallography [PDF]
Methods, 2017 Crystallography is a powerful tool to determine the atomic structures of proteins and RNAs. X-ray crystallography has been used to determine the structure of many splicing related proteins and RNAs, making major contributions to our understanding of the molecular mechanism and regulation of pre-mRNA splicing.
Sara, Espinosa +3 more
openaire +2 more sources
Interaction of hnRNPA1/A2 and DAZAP1 with an Alu-derived intronic splicing enhancer regulates ATM aberrant splicing. [PDF]
PLoS ONE, 2011 We have previously identified an Alu-derived Intronic Splicing enhancer (ISE) in the Ataxia Teleangectasia Mutated gene (ATM) that facilitates intron pre-mRNA processing and leads to the inclusion of a cryptic exon in the final mRNA transcript.
Tibor Pastor, Franco Pagani
doaj +1 more source
Neurotrauma Reports, 2022 To determine molecular changes that correlate with long-term physiological changes after spinal cord injury associated with spasticity, we used a complete transection model with an injury at sacral spinal level S2, wherein tail spasms develop in rats ...
Samantha N. Hart +9 more
doaj +1 more source
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors [PDF]
, 1994 We have examined the functional significance of the organization of pre-mRNA splicing factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into living cells of oligonucleotides or antibodies that inhibit pre-mRNA splicing
Krainer, A. R. +4 more
core +2 more sources
PLoS ONE, 2020 Pre-mRNA splicing is critical for achieving required amounts of a transcript at a given time and for regulating production of encoded protein. A given pre-mRNA may be spliced in many ways, or not at all, giving rise to multiple gene products.
Hsin-Hao T Hsiao +5 more
doaj +1 more source
Journal of Pharmacological Sciences, 2016 The two-pore domain K+ channel K2P5.1 has been implicated in the pathogenesis of autoimmune diseases. We investigated the changes in K2P5.1 activity caused by a defect in normal pre-mRNA splicing in concanavalin A-activated mouse splenic CD4+ T cells ...
Kazutaka Tagishi +6 more
doaj +1 more source
Splicing of the U6 RNA precursor is impaired in fission yeast pre-mRNA splicing mutants [PDF]
, 1989 U6 RNA is a member of a class of small abundant stable nuclear RNAs that are essential for splicing. In all species examined so far, the U6 RNA is a RNA polymerase III transcript.
Potashkin, J., Frendewey, D.
core +1 more source
Abnormal splicing of ABCA1 pre-mRNA in Tangier disease due to a IVS2 +5G>C mutation in ABCA1 gene
Journal of Lipid Research, 2003 Two point mutations of ABCA1 gene were found in a patient with Tangier disease (TD): i) G>C in intron 2 (IVS2 +5G>C) and ii) c.844 C>T in exon 9 (R282X).
Serena Altilia +12 more
doaj +1 more source
Splicing therapeutics in SMN2 and APOB [PDF]
, 2009 Splicing therapeutics are defined as the deliberate modification of RNA splicing to achieve therapeutic goals. Various techniques for splicing therapeutics have been described, and most of these involve the use of antisense oligonucleotide-based ...
Khoo, B., Krainer, A. R.
core
Regulation of gonadotropin receptor gene expression [PDF]
, 1994 The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons.
Grootegoed, J.A. (Anton) +2 more
core +1 more source