Results 231 to 240 of about 270,676 (398)

A Genetically Encoded Homocysteine Precursor to Probe Protein Active Sites and to Addict Escherichia coli to a Noncanonical Amino Acid Directly Involved in Catalysis

Angewandte Chemie, EarlyView.
A new genetically encoded amino acid is chemically converted into homocysteine (Hcy) under mild conditions to probe and to activate protein active sites. Surprisingly, Hcy can replace cysteine or serine residues in several enzymes. Its potential for a widespread use in proteins is further underlined by rendering Escherichia coli dependent on Hcy ...
Clara Dunker, Henning D. Mootz
wiley   +2 more sources

Swt21p Is Required for Nam8p-U1 snRNP Association and Efficient Pre-mRNA Splicing in <i>Saccharomyces cerevisiae</i>. [PDF]

Int J Mol Sci
Lin K, Fu X, Wang L, Xiao S, Wang S, Fan Y, An X, Boon KL, Bao P.   +8 more
europepmc   +1 more source

Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT

Advanced Science, EarlyView.
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai, Yining Zheng, Bo Sun, Guoyan Wang, Pengfei Li, Huijun Geng, Rongnuo Li, Miaomiao Zhu, Yuanyuan Zhu, Dingping Feng, Lei Chen, Guiyan Chu, Lu Deng, Shiyan Qiao   +13 more
wiley   +1 more source

Protocol to study the effects of mutations near splicing sites on pre-mRNA splicing. [PDF]

STAR Protoc
Xie D, Peng Q, Tian Y, Han Y, Lu G.
europepmc   +1 more source

DHX38 restricts chemoresistance by regulating the alternative pre-mRNA splicing of RELL2 in pancreatic ductal adenocarcinoma. [PDF]

PLoS Genet, 2023
Li Z, Qin C, Zhao B, Wang Y, Li T, Zhao Y, Wang W.   +6 more
europepmc   +1 more source

Addressing the Diagnostic Odyssey for Adults With Neurodevelopmental Disabilities: Case Study of an Individual With Mandibulofacial Dysostosis With Microcephaly

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Whole exome sequencing (WES) has been widely used in the pediatric setting to increase diagnostic yield, provide treatment options, and to estimate reoccurrence risks. However, there is limited knowledge regarding the utility of this technology in adults with neurodevelopmental disabilities.
Ruhi Shah, Neora Shifrin, Mary Ellen Keogh, Elaine Marchi, Maureen Gavin, Karen Amble, Gholson J. Lyon   +6 more
wiley   +1 more source

SRSF10 regulates oligodendrocyte differentiation during mouse central nervous system development by modulating pre-mRNA splicing. [PDF]

Nucleic Acids Res
Mu Y, Wei Z, Sun M, Li J, Jiang Y, Jiang H, Ma A, Zhu C, Chen X.   +8 more
europepmc   +1 more source

A novel single nucleotide mutation of TFL1 alters the plant architecture of Gossypium arboreum through changing the pre-mRNA splicing. [PDF]

Plant Cell Rep, 2023
Liu J, Miao P, Qin W, Hu W, Wei Z, Ding W, Zhang H, Wang Z.   +7 more
europepmc   +1 more source

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.

, 1993
Z. Dominski, R. Kole
openalex   +2 more sources

Inhibition of viral growth by an α‐oligonucleotide directed to the splice junction of Herpes simplex virus type‐1 immediate‐early pre‐mRNA species 22 and 47 [PDF]

, 1993
A. Jacob, G Duval-Valentin, D Ingrand, Nguyen T. Thuong, Claude Hélène   +4 more
openalex   +1 more source