How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
core +1 more source
Profiling Pre-Replication Complex Mutations in Cancer [PDF]
, 2023 Book of abstract: 4th Belgrade Bioinformatics Conference, June 19-23 ...
Kusić Tisma, Jelena +4 more
openaire
Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways
Cell Division, 2007 In eukaryotes, DNA replication is strictly regulated so that it occurs only once per cell cycle. The mechanisms that prevent excessive DNA replication are focused on preventing replication origins from being reused within the same cell cycle.
Kim Youngjo, Kipreos Edward T
doaj +1 more source
Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]
, 2020 DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan +2 more
core +1 more source
Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2016 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco +11 more
core +4 more sources
NFIB facilitates replication licensing by acting as a genome organizer
Nature Communications, 2023 The chromatin-based rule governing the selection and activation of replication origins in metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear Factor I (NFI) family that was initially purified in host cells to promote ...
Wenting Zhang +17 more
doaj +1 more source
Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus [PDF]
Nucleic Acids Research, 2003 The eukaryotic pre-replication complex is assembled at replication origins in a reaction called licensing. Licensing involves the interactions of a variety of proteins including the origin recognition complex (ORC), Cdc6 and the Mcm2-7 helicase, homologues of which are also found in archaea.
Ian, Grainge +2 more
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Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex [PDF]
, 1998 The Xenopus origin recognition complex is essential for chromosomal DNA replication in cell-free extracts. We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies and analyzed its composition and properties.
Carpenter, Phillip B. +1 more
core +1 more source
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +1 more source
Genome based identification and analysis of the pre‐replicative complex of Arabidopsis thaliana [PDF]
FEBS Letters, 2004 Eukaryotic DNA replication requires an ordered and regulated machinery to control G1/S transition. The formation of the pre‐replicative complex (pre‐RC) is a key step involved in licensing DNA for replication. Here, we identify all putative components of the full pre‐RC in the genome of the model plant Arabidopsis thaliana.
Masuda, H.P. +7 more
openaire +2 more sources