Results 31 to 40 of about 593,420 (263)

The Role of Pre-School Education in the Child’s Development and Analysis of Current Pre-School Education System in Uzbekistan

Journal of Vasyl Stefanyk Precarpathian National University, 2021
The author of the article attempts to analyze the current pre-school education system of Uzbekistan, its main challenges, shortcomings and reforms. Moreover, this research will provide the study of the importance of learning at early ages (3-5) and its impact on the future learning and personal development of children.
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A Local–Global Graph KAN for Multi‐Class Prediction of PPI

Engineering Reports
Traditional experimental methods for identifying protein–protein interactions (PPI) are expensive and time‐consuming. Therefore, using machine learning to treat multiple PPI predictions as binary classifications has become an alternative, but there is a ...
Minghui Liu, Ying Qu
doaj   +1 more source

Determination of chlorite in water by resonance scattering spectrometry with Methylene blue

Gongye shui chuli
In CH3COONa-HCl buffer solution, ClO2- oxidizes excess I- to generate I3-, and I3- forms complex particles with positively charged methylene blue under electrostatic attraction, which enhances the resonance scattering intensity of the system.
HUANG Nianhua, HUANG Silin, LU Hongye, MA Lu, LING Shaoming   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Burnout Syndrome Among Educators in Pre-school Institutions [PDF]

Materia Socio Medica, 2015
The occurrence of burnout syndrome (BS) has been recognized in many professions (pilots, firefighters, police officers, doctors…) that during their work are subjected to high levels of stress. For educators in preschool institutions stress level is very high thus creating the possibility of developing BS.For this research is selected preschool ...
Radić Hozo, Endica, Sučić, Goran, Žaja, Ivan   +2 more
openaire   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The importance of physical education classes in pre‐school children [PDF]

Journal of Paediatrics and Child Health, 2010
Aim:  The purpose of this study was to analyse differences between total physical activity (TPA) and moderate‐to‐vigorous PA (MVPA) of pre‐school children during daily school hours when they attended the physical education class (PED) and school days without PE class (NPED) and to assess the contribution of PE classes to TPA in school hours.Methods ...
Vale, Susana, Santos, Rute, Soares-Miranda, Luisa, Silva, Pedro, Mota, Jorge   +4 more
openaire   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source