Results 61 to 70 of about 17,661,005 (279)

Hungarian vocational education teachers’ views on their pedagogical knowledge and the information sources suitable for their professional development

Empirical Research in Vocational Education and Training, 2018
Background Vocational education teachers are key participants in the renewal of the Hungarian vocational educational system. Their professional development (as indicated by their learning activities, learning targets and information sources) contains ...
Csaba Csíkos, Zsuzsa Kovács, Orsolya Kereszty   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Promoting girls in sport – (Still) in keeping with the times?

Current Issues in Sport Science
Introduction “Promoting girls in sport”: How to find an interview partner for this topic? In their search, the editors of the Swiss girls’ magazine ‘KALEIO – For Girls (and the Rest of the World)’ learnt that the topic is ‘out’.
Elke Gramespacher
doaj   +1 more source

TIME-MANAGEMENT AS AN EFFECTIVE MEANS OF MANAGING TIME FOR EDUCATION INSTITUTION EMPLOYEE

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
In today’s world private time is a key resource for any person, which often has even a higher value than money. Competent managing one’s time resource implies adequate assessment of the situation, making relevant decisions with due regard to time costs ...
Tatiana E. Simina, Tatiana A. Zalygina
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The role of the school innovative climate in the relationship between proactive personality and creative behavior among students from Chinese normal colleges

Humanities & Social Sciences Communications
As China advances towards becoming an innovation-driven nation, nurturing creativity in normal college students—future educators—is crucial, as it enhances their teaching strategies and supports the cultivation of innovative talents essential for ...
Yun Cai
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effective pre-school, primary and secondary education project (EPPSE 3-14) : students' reports of their experiences in year 9 [PDF]

, 2011
The Effective Pre-school, Primary and Secondary Education Project (EPPSE) has inves tigated the academic and social behavioural (+ in the later stages the affective) development of approximately 3,000 children from the age of 3+ years since 1997.
Smees, R., Draghici, D., Smees, R, Siraj-Blatchford, Iram, Toth, Katalin, Taggart, Brenda, Taggart, B., Sylva, K., Melhuish, E, Sammons, Pam, Sammons, P., Siraj-Blatchford, I, Sammons, Pamela, Draghici, Diana, Sammons, P, Draghici, D, Smees, Rebecca, Sylva, K, Sylva, Kathy, Toth, K, Toth, K., Siraj-Blatchford, I., Melhuish, Edward, Melhuish, Edward C., Taggart, B   +24 more
core   +1 more source

SUPERVISION OF PRE-SCHOOL CHILDREN AND PHYSICAL EDUCATION [PDF]

Southern Medical Journal, 1921
n ...
openaire   +1 more source