Results 151 to 160 of about 2,498,929 (340)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Typical investigative situations in the initial phase of a war-related sexual violence investigation

Bulletin of Kharkiv National University of Internal Affairs
A comparative analysis of scientific provisions regarding the phasing of the pretrial investigation process and the content of the concept of “investigative situation” has been conducted.
O. O. Naumkin
doaj   +1 more source

Методичні рекомендації щодо особливостей досудового розслідування стосовно окремої категорії осіб [PDF]

, 2013
Методичні рекомендації щодо особливостей досудового розслідування стосовно окремої категорії осіб / Юхно О.О., Бондаренко О.О., Глобенко Г.І. та ін. // Актуальні питання діяльності слідчих підрозділів органів внутрішніх справ України : зб. наук. пр. ф-ту
Bondarenko, O. O., Chycha, R. P., Danylenko, A. V., Globenko, G. I., Kochura, O. O., ORCID: http://orcid.org/0000-0001-6077-4591, ORCID: http://orcid.org/0000-0001-6901-7298, ORCID: http://orcid.org/0000-0002-1452-5815, ORCID: http://orcid.org/0000-0002-1533-9213, ORCID: http://orcid.org/0000-0002-4771-0531, ORCID: http://orcid.org/0000-0002-7721-2955, ORCID: http://orcid.org/0000-0003-3267-2840, ORCID: http://orcid.org/0000-0003-0638-2911, Romaniuk, V. V., Sychov, S. O., Yukhno, O. O., Бондаренко, О. О., Глобенко, Г. І., Даниленко, А. В., Кочура, О. О., Романюк, В. В., Сичов, С. О., Чича, Р. П., Юхно, О. О.   +23 more
core  

European Court of Human Rights : Beizaras and Levickas v. Lithuania [PDF]

, 2020
In a case about hate speech against homosexuals on Facebook, the European Court of Human Rights (ECtHR) delivered an important and well-documented judgment (of 61 pages.) The ECtHR found that the Lithuanian authorities have violated the European ...
Voorhoof, Dirk
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

THE PROBLEMS OF REGULATING THE POWERS OF THE PROSECUTOR TO SUPERVISE THE PROCEDURAL ACTIVITIES OF THE BODIES OF INQUIRY AND PRELIMINARY INVESTIGATION

Хабаршы. Заң сериясы
The article examines the current state of law enforcement practice; theoretical, legal and organizational foundations of the prosecutor's supervision of the criminal procedural activities of the bodies conducting pre-trial investigation; issues of the ...
Г.Н. Мухамадиева, Е.Т. Алимкулов, А.К. Жанибеков, А.Б. Шарипова, Н.М. Апсимет   +4 more
doaj  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Application of the principle of retroactivity in ukrainian legislation for commitment of applicable offenses against property

Науково-інформаційний вісник Івано-Франківського університету права імені Короля Данила Галицького
Purpose. The purpose of the work is to study the extension of the principle of retroactivity to law-making and law-enforcement practice to the legal system in Ukrainian legislation. Methodology.
Lototskyi M., Dzundza L.
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source