Results 71 to 80 of about 747,457 (309)

Contaminating the Verdict: The Problem of Juror Misconduct [PDF]

, 2004
This article describes the myriad ways in which misconduct by jurors can contaminate a trial and verdict and the ability of courts to remedy such misconduct.
Gershman, Bennett L.
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

PRE-TRIAL PROCEEDINGS: PROSPECTS OF DEVELOPMENT

Juridical Journal of Samara University, 2019
The article analyzes the problems and prospects of development of pre-trial proceedings and its place in the criminal procedure system. Almost two decades have passed since the adoption and entry into force of the Criminal Procedure Code of the Russian Federation a sufficient period to think about the prospects for further development of criminal ...
openaire   +2 more sources

Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування [PDF]

, 2015
Паршак, С. А. Деякі аспекти забезпечення прав учасників кримінального провадження під час ознайомлення з матеріалами досудового розслідування / Паршак Сергій Анатолійович // Наше право. - 2015. - № 4. - С. 126-130.Паршак С. А. "Деякі аспекти забезпечення
Parshak, S. A., Паршак, С. А.
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

On the implementation of the law enforcement function of the state in criminal procedure

Jus Strictum
The paper presents the author’s vision of the organization of balanced pre-trial proceedings based on the functional delineation of the activities of state authorities ensuring the fulfillment of public-law duties of the state in criminal procedure ...
Svetlana I. Vershinina
doaj   +1 more source

Щодо визначення місця та функцій органів досудового розслідування в системі кримінальної юстиції України [PDF]

, 2015
Голубов А. Є. Щодо визначення місця та функцій органів досудового розслідування в системі кримінальної юстиції України / Голубов Артем Євгенович // Теоретичні аспекти організації досудового розслідування : матеріали Всеукр. наук.-практ. конф. (м. Харків,
Holubov, A. Ye., ORCID: http://orcid.org/0000-0001-8608-4206, Голубов, А. Є.   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

System of International Legal Standards for Ensuring Human Rights and Freedoms at the Pre-trial Investigation Stage

Bulletin of Kharkiv National University of Internal Affairs
It is emphasised that the system of international legal standards for ensuring human rights and freedoms at the pre-trial investigation stage is fundamental to any democratic state governed by the rule of law.
S. M. Danylo
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source