Results 71 to 80 of about 4,353 (174)

Preanalytical variables affect predictive immunohistochemical biomarker testing in non–small cell lung carcinoma cytology specimens

Cancer Cytopathology, Volume 134, Issue 11, November 2026.
Abstract Background Several therapeutic targets for non–small cell lung carcinoma (NSCLC) rely on protein expression by immunohistochemistry (IHC). Most biomarkers are validated on formalin‐fixed, paraffin‐embedded (FFPE) tissue; however, cytologic specimens, including cell blocks (CBs), that are subject to preanalytical variables are increasingly used.
Saroja Devi Geetha, Wei‐Lien Wang, Neda Kalhor, Sinchita Roy‐Chowdhuri   +3 more
wiley   +1 more source

Toward a digital urinary biopsy for early risk stratification in diabetic kidney disease: Anchoring shed cells, vesicles, and cell‐free DNA to spatial kidney cell states

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
In diabetic kidney disease, one urine specimen carries shed cells, extracellular vesicles and cell‐free DNA released along the whole nephron. Reading all three against spatial kidney atlases is proposed as a testable route to cell‐resolved, non‐invasive risk stratification, and the clinical outputs shown are not yet demonstrated.
Juan Wu, Ping Sheng, Ying Lu, Ke Chen
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

Decoverslipping of Archival Cytology Aspirate Smears for Ancillary Studies: A Review of Methods and Institutional Experience With Freezer‐Based Techniques

Cytopathology, Volume 37, Issue 6, Page 574-586, November 2026.
Freezer‐based decoverslipping of archival cytology aspirate smears achieved only 32.5% slide‐level success (26/80), with mounting medium composition and coverslip material, not freezing temperature or duration, identified as dominant determinants, underscoring the need to align coverslipping practices with anticipated ancillary testing requirements ...
Nyein Nyein Htun, Sinchita Roy‐Chowdhuri, Benjamin B. Morris, Gloria Hopkins Sura   +3 more
wiley   +1 more source

Evaluation of thyroglobulin autoantibodies in dogs at the time of diagnosis of hypoadrenocorticism and during treatment

Veterinary Record, Volume 199, Issue 8, Page e350-e358, 17/24 October 2026.
Abstract Background Autoimmune thyroiditis (AIT) may occur more frequently in dogs with hypoadrenocorticism (HA) than previously recognised. The objective of this study was to determine the presence of thyroglobulin autoantibodies (TgAAs) in dogs with HA.
Christin Emming, Sina Strey, Ina Leiter, Reinhard Mischke, Holger Volk, Marion Schmicke, Johanna Rieder   +6 more
wiley   +1 more source

Direct cost analysis for 32,783 samples with preanalytical phase errors. [PDF]

North Clin Istanb, 2022
Eker P.
europepmc   +1 more source

Impact and frequency of IV fluid contamination on basic metabolic panel results using quality metrics

Journal of Laboratory Medicine
Clinical laboratories invest substantial time and resources to mitigate measurement error but potential errors during the preanalytical phase of testing are not subjected to the same level of scrutiny. Herein, we assess the proportions of intravenous (IV)
Spies Nicholas C., Farnsworth Christopher W.   +1 more
doaj   +1 more source

Rules of Blood Sampling and Storage for Laboratory Studies

Общая реаниматология, 2008
Objective: to review and to systematize the recommendations on reducing the incidence of defects occurring with a sample of blood after its sampling in the preanalytical phase and the impact of these shifts on the correct interpretation of a patient ...
A. Ye. Muronov, I. B. Zabolotskikh
doaj   +1 more source

Impact of Pneumatic Transport System on Preanalytical Phase Affecting Clinical Biochemistry Results. [PDF]

J Lab Physicians, 2023
Kumari S, Kumar S, Bharti N, Shekhar R.
europepmc   +1 more source

Re-evaluating haemolysis rejection criteria for PT, aPTT, and D-dimer testing: evidence from paired clinical samples on the CN-3000 analyser

Advances in Laboratory Medicine
Haemolysis is the leading preanalytical cause of sample rejection in coagulation testing. This study prospectively evaluated the impact of spontaneous haemolysis on routine haemostasis assays by comparing paired haemolysed (H) and non-haemolysed (NH ...
Kaewkhruawan Jirapa, Masalae Wararat, Tanticharoenkarn Surapat, Riyagoon Pitchayaporn, Laiklang Waroonkarn, Chaiwong Kwanlada, Wongkamchai Suppakorn, Watanaboonyongcharoen Phandee, Ketloy Chutitorn, Limpornpugdee Orakan, Prompetchara Eakachai   +10 more
doaj   +1 more source