Results 51 to 60 of about 8,264 (228)

Nucleosomes in pancreatic cancer patients during radiochemotherapy [PDF]

, 2005
Nucleosomes appear spontaneously in elevated concentrations in the serum of patients with malignant diseases as well as during chemo- and radiotherapy. We analyzed whether their kinetics show typical characteristics during radiochemotherapy and enable an
Amoura Z, Andreas Kremer, Arends MJ, Dietrich Seidel, Dorothea Nagel, Gauthier VJ, Heinemann V, Holdenrieder S, Ishii H, Kerr JF, Kuroi K, Lo YM, Meyn RE, Petra Stieber, Ralf Wilkowski, Rumore P, Stefan Holdenrieder, Szumiel I, Wilkowski R, Wyllie AH   +19 more
core   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, EarlyView.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source

System hazards in managing laboratory test requests and results in primary care: medical protection database analysis and conceptual model [PDF]

, 2015
Objectives To analyse a medical protection organisation's database to identify hazards related to general practice systems for ordering laboratory tests, managing test results and communicating test result outcomes to patients.
Bowie, Paul, Dinwoodie, Mark, Hepworth, Neil, McKay, John, Price, Julie   +4 more
core   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

Improving the preanalytical process: the focus on specimen quality [PDF]

Journal of Medical Biochemistry, 2008
Trends in clinical laboratory practice place more demands on the quality of patient specimens. Advances in analytical performance (i.e., increased automation, reduced sample volume, increased assay sensitivity), as well as efficiency and cost reduction ...
Green Sol
doaj  

The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans [PDF]

, 2015
INTRODUCTION: We describe Alzheimer's Disease Neuroimaging Initiative (ADNI) Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ1-42), t-tau, and p-tau181 analytical performance, definition of Alzheimer's disease ...
Aisen, Paul S., Alzheimer's Disease Neuroimaging Initiative, Blennow, Kaj, Brylska, Magdalena, Dean, Robert A., Fields, Leona, Figurski, Michal J., Kang, Ju-Hee, Korecka, Magdalena, Petersen, Ronald C., Saykin, Andrew J., Shah, Nirali, Shaw, Leslie M., Soares, Holly, Toledo, Jon B., Trojanowski, John Q., Vanderstichele, Hugo, Waligorska, Teresa, Weiner, Michael W., Zetterberg, Henrik   +19 more
core   +1 more source

Influence of Different Washing Hair Procedures in the Quantitative Determination of THC and THCCOOH

Drug Testing and Analysis, EarlyView.
Different hair decontamination protocols significantly affect THC quantification, with marked analyte loss—particularly after aqueous‐organic washing—whereas THCCOOH remains stable. These findings highlight the risk of misinterpretation and the need for standardized washing procedures in hair analysis.
Valentina Martini, Alessandro Raffagli, Cristiana Stramesi, Claudia Vignali, Stefania Ortu, Paolo Franceschini, Ilaria Baudone, Paolo Bucchioni, Luca Morini   +8 more
wiley   +1 more source

Establishment and implementation of an improvement plan using Lean Six Sigma methodology to minimize variation in ordering laboratory tests

Journal of the Arab Society for Medical Research, 2022
Background/aim Ordering laboratory (laboratory) tests by physicians is a part of the pre-preanalytical laboratory phase, which is a high error-prone process.
Salwa H Gomaa, Mona M Abaza, Reham M Rashwan, Nabil L Dowidar, Ola H Elgaddar   +4 more
doaj   +1 more source

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network [PDF]

, 2009
Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.
Frölich, Lutz, Gertz, Hermann-Josef, Hampel, Harald, Henn, Fritz, Heuser, Isabella, Huell, Michael, Jahn, Holger, Jessen, Frank, Kornhuber, Johannes, Luckhaus, Christian, Maier, Wolfgang, Pantel, Johannes, Perneczky, Robert, Peters, Oliver, Rienhoff, Otto, Ruüther, Eckart, Schmidtke, Klaus, Schroeder, Johannes, Seuchter, Susanne A., Weih, Markus, Wiltfang, Jens, Wolf, Stefanie   +21 more
core   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source