Results 71 to 80 of about 4,915 (175)

The Impact of Melatonin Supplementation on Various Aspects of Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Polycystic ovary syndrome (PCOS) is a prevalent gynecological condition affecting women of reproductive age, with implications for multiple aspects of women's health. Recent research indicates that melatonin (MLT) may enhance several dimensions of this syndrome via various mechanisms. Consequently, this study was undertaken
Seyedeh Shahed Shoarishoar, Zainab Alimoradi, Fatemeh Alsadat Rahnemaei, Saeed Mehrzadi, Fatemeh Abdi   +4 more
wiley   +1 more source

Impact of Neutral Sphingomyelinase Inhibition on Small Extracellular Vesicle Production by Mural Granulosa Cells and In Vitro Folliculogenesis in Mice

Molecular Reproduction and Development, Volume 92, Issue 10, October 2025.
ABSTRACT Small extracellular vesicles (sEVs) function as critical regulators of ovarian follicular development. Although several pathways, including one involving neutral sphingomyelinase (nSMase), contribute to sEV production, the specific pathway active in ovarian follicles has not been clearly identified.
Kodai Matsushita, Yuta Matsuno, Kazuma Kita, Ayaka Ichikawa, Natsumi Maruyama, Wataru Fujii, Tsutomu Endo, Koji Sugiura   +7 more
wiley   +1 more source

Compound Heterozygous Variants in ZSWIM7 Gene Linked to Infertility and Its Role in Gonadal Development

American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT This study aims to elucidate the role of the ZSWIM7 gene in the etiology of infertility, focusing on its potential association with premature ovarian insufficiency and azoospermia. We investigated an 18‐year‐old female patient who presented with primary amenorrhea, hypoplasia of the uterus and ovaries, Tanner stage II breast and pubic hair ...
Denise M. Christofolini, Guilherme Pinn, Thainá Vilella, Maria I. Melaragno, Mariana Moysés‐Oliveira, Luciano Pompei, Rare Genomes Project Consortium, Bianca Bianco, Caio P. Barbosa   +8 more
wiley   +1 more source

Anti‐Müllerian Hormone Levels Are Associated With Skeletal Maturity in Adolescent Girls: A Longitudinal Study

Health Science Reports, Volume 8, Issue 9, September 2025.
ABSTRACT Background and Aims The role of anti‐Müllerian hormone (AMH), a potential marker of the hypothalamic–pituitary–ovarian axis, is not well established in adolescent females. Typical epidemiologic studies use secondary sexual characteristics or chronological age as predictors for AMH.
McKenzie L. Ford, Audrey C. Choh, Brandon Gonzalez, Steven R. Lindheim, Frank Z. Stanczyk, Lynda K. McGinnis, Stefan A. Czerwinski, Miryoung Lee   +7 more
wiley   +1 more source

GADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and Mice

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses
Juncen Guo, Yuanyuan Hu, Qi Cao, Ying Zhang, Yihe Jia, Lan Liu, Yanru Zeng, Xiao Wu, Yuelin Song, Maosen Yang, Wenming Xu, Yang Hu, Wei Huang, Tian Tang   +13 more
wiley   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Morphological characterization and isolation of preantral follicles in Chianina cows reared in Tuscany

Italian Journal of Animal Science, 2011
In the last decade some isolation procedures were developed to obtain an increase in the number of progeny born per dam from a high number of oocytes manipulated in vitro (Telfer, 1996).
A. Giorgetti, A. Martini, B. Gaspardo, C.A. Amorim, D. Rondina   +4 more
doaj   +1 more source

The art of oocyte meiotic arrest regulation

Reproductive Biology and Endocrinology, 2019
A central dogma of mammalian reproductive biology is that the size of the primordial follicle pool represents reproductive capacity in females. The assembly of the primordial follicle starts after the primordial germ cells (PGCs)-derived oocyte releases ...
Bo Pan, Julang Li
doaj   +1 more source

Histological assessment for investigation of dose-dependent ovarian toxicity of cyclophosphamide in the rat

Heliyon
Background: Cyclophosphamide (CPA) have significant effects on ovarian follicles which lead to ovarian toxicity and impair the normal female reproductive function.
Narges Elahi, Mohammad Ebrahim Astaneh, Jafar Ai, Zohreh Makoolati   +3 more
doaj   +1 more source

Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary

Frontiers in Physiology, 2018
There is an increasing recognition that vitamin D plays important roles in female reproduction. Recent studies demonstrated that 1α,25-dihydroxyvitamin D3 (VD3), the biologically active form of vitamin D, improved ovarian follicle survival and growth in ...
Jing Xu, Jing Xu, Maralee S. Lawson, Fuhua Xu, Yongrui Du, Yongrui Du, Olena Y. Tkachenko, Cecily V. Bishop, Lucas Pejovic-Nezhat, David B. Seifer, Jon D. Hennebold, Jon D. Hennebold   +11 more
doaj   +1 more source