Results 101 to 110 of about 116,118 (329)
Poly(ethylene Glycol)‐Based Peptidomimetics (Pegtides) of Antimicrobial Peptides
ChemBioChem, EarlyView.Polyethylene glycol (PEG) is commonly used to improve the pharmacokinetics and pharmacodynamics of therapeutic candidates by conjugation. Here PEG is exploited for peptidomimetic conversion of antimicrobial peptides (AMPs), as candidate antibacterial agents, by replacing their polyamide backbone. The pegtides obtained thereby can be readily synthesized
Conor Shine +13 more
wiley +1 more source
Phenolic Composition and Arabinoxylan Characterization of Pearled Barley Fractions
Cereal Chemistry, EarlyView.ABSTRACT Background and Objectives Two hulless barley varieties (Peru‐35 and Roseland) were pearled into six fractions and analyzed for primary phenolic acids via HPLC, along with the arabinoxylan content and degree of substitution (arabinose to xylose (A/X) ratio) using gas chromatography.
Pamela Drawbridge +2 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Evidence is presented that prebiotically accessible mellitic (benzenehexacarboxylic) acid (MAc) is forming liquid droplets with short poly‐L‐lysine. The capacity of MAc to induce liquid‐liquid phase separation with short oligocations, along with abiotic synthesis routes, makes MAc a viable candidate for an ingredient of early prebiotic membraneless ...
Robert Dec +4 more
wiley +1 more source
Chemistry–Methods, EarlyView.Self‐assembly of guanosine‐5′‐monophosphate into G‐quadruplexes induces a cation‐specific (sodium vs. potassium), intense terahertz Raman optical activity signal. The supramolecular helical arrangement gives rise to a distinct chiral vibrational signature in the low‐frequency region.
Štěpán Jílek +2 more
wiley +1 more source
Impact of Carbohydrates on the Aggregation of Probiotic Bacteria [PDF]
, 2014 Probiotic bacteria can be beneficial to the gastrointestinal tract in the human body in numerous ways. Autoaggregation may play a key role in allowing probiotics to prevent pathogenic organisms from colonizing the intestinal system. Currently, scientific
Davis, Kennedy
core
Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease
Frontiers in Neurology, 2019 Parkinson's Disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Recent evidence supports the involvement of the gastrointestinal tract in PD pathogenesis, including alterations in microbiota
T. Cantu-Jungles +2 more
semanticscholar +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler +4 more
wiley +1 more source
A model for the emergence of cooperation, interdependence and structure in evolving networks
, 2000 Evolution produces complex and structured networks of interacting components in chemical, biological, and social systems. We describe a simple mathematical model for the evolution of an idealized chemical system to study how a network of cooperative ...
Bak +8 more
core +2 more sources
Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance How did the first cells on Earth arise? In a minimal cell, a membrane separates proteins and RNA from the surrounding aqueous environment.
Caitlin E. Cornell +11 more
semanticscholar +1 more source
Gut‐microbiota‐brain Axis and post‐traumatic epilepsy
Epilepsia Open, EarlyView.Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley +1 more source