Results 71 to 80 of about 7,504 (283)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Precedent Names from the Source Domain "Politics" in the UK Mass Media (2010-2019)

, 2020
The paper deals with precedent names derived from source domain "Politics" in the mass media of the UK (The Guardian, The Times.В статье рассматриваются прецедентные имена из сферы-источника "Политика", функционирующие в британских печатных ...
Budaev, E. V., Будаев, Э. В., Shcherbinina, P. P., Щербинина, П. П.   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dynamic reconfiguration of the language network preceding onset of speech in picture naming [PDF]

Human Brain Mapping, 2014
AbstractLanguage production is a complex neural process that requires the interplay between multiple specialized cortical regions. We investigated modulations in large‐scale cortical networks underlying preparation for speech production by contrasting cortico‐cortical coherence for overt and silent picture naming in an all‐to‐all connectivity analysis.
Liljeström Mia, Salmelin Riitta, Liljeström Mia, Liljeström Mia, Stevenson Claire, Kujala Jan   +5 more
openaire   +5 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Prometheus, Hercules, Icarus, etc.: About precedent nouns-mythonyms in the modern Greek language

Шаги
The article deals with some linguistic aspects of the functioning of Greek mythological proper names (gods, heroes etc.), which became precedent nouns-mythonyms in the Modern Greek language, expanding their semantic structure.
I. V. Tresorukova
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pragmatics of precedent names in the texts of the newspapers published in English / M. S. Matveeva

, 2019
Раздел 4. Литературоведение, перевод и интерпретация текста = Section 4. Literature studies, translation and text interpretationНастоящая статья посвящена проблеме использования прецедентных имен в текстах англоязычных газет.
Матвеева, М. С.
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Detective text of post-modernism: precedential phenomena as linguacultural markers of intertexuality

Известия Южного федерального университета: Филологические науки, 2015
Detective postmodern text is characterized by active functioning of gaming modality, which is partly responsible for its inclusion in the semantic space of precedent phenomena.
Tuova Ruzana Hamedovna
doaj   +1 more source