Results 81 to 90 of about 7,504 (283)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Transformation of precedent names in the Ukrainian humoristic discourse 2022–2024
, 2023 Статтю присвячено дослідженню мовних механізмів трансформації прецедентних імен в українському гумористичному дискурсі воєнного часу. Метою дослідження обрано виявлення структурно‑семантичних та комунікативно‑ прагматичні особливостей інноваційних ...
Shevchuk, Larysa V. +1 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
, 2017 The present study is complied with the topical theme “name in the text” and devoted to the problems of how precedent names as the text-forming elements function in the poems and prose works of Marina Tsvetaeva within the framework of free indirect ...
Daniya Abuzarovna Salimova +1 more
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Precedent names of writers in the poems of M. Tank: semantic-functional plan [PDF]
, 2022 У артыкуле праз спалучэнне прыёмаў фенаменалагічнага і дэскрыптыўнага метадаў вызначаецца роля прэцэдэнтных імёнаў у вершах Максіма Танка ў выяўленні эстэтычна-аксіялагічных інтэнцый аўтара. Сцвярджаецца, што прэцэдэнтныя імёны ў паэзіі М. Танка сведчаць
Бароўка, В. Ю.
core
Известия Южного федерального университета: Филологические науки, 2019 The proper name in the texts of the media is one of the ways to express the author’s modality, appraisal and a means of attracting the attention of the reader.
Elena V. Glinka
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source