Results 141 to 150 of about 34,352 (289)

Strengthening Treaty Understanding: The Role of Education in Building Durable Indigenous–State Agreements

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT Education is a central mechanism for ensuring that Indigenous–State treaties are understood, supported and endure through political change. Public knowledge shapes the negotiation, acceptance, implementation and long‐term stability of agreements. In Australia, however, treaty knowledge remains fragmented.
Jacob Prehn, Harry Hobbs, Jessica Horton
wiley   +1 more source

Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening

open access: yesAngewandte Chemie, EarlyView.
Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker   +3 more
wiley   +2 more sources

REFLEXÃO ACERCA DA APLICAÇÃO DOS PRECEDENTES JUDICIAIS

open access: yes, 2018
O presente trabalho possui o objetivo de analisar os precedentes judiciais através de um aspecto negativo, isto é, refletir acerca dos impactos prejudiciais da utilização dos precedentes nos processos judiciais.
Franche, Suzan Raphaellen
core  

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

open access: yesAnnals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral   +52 more
wiley   +1 more source

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

open access: yesAngewandte Chemie, EarlyView.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson   +5 more
wiley   +2 more sources

Os precedentes judiciais no ordenamento jurídico brasileiro [PDF]

open access: yes, 2015
O presente trabalho de conclusão do curso de Especialização tem o escopo de apresentar um estudo a respeito dos Precedentes Judiciais à comunidade acadêmica em geral, não somente à comunidade jurídica.
Chincoli, Vanessa Kerpel
core  

Del precedente constitucional al nuevo precedente contencioso administrativo

open access: yes, 2011
Este es un trabajo más bien descriptivo que analítico, en el cual se pretende mostrar cual es el uso del precedente en el ordenamiento colombiano, tanto en materia constitucional como ahora en materia contencioso administrativa, debido a la importancia que uno mismo ha adquirido en todas las jurisdicciones que tienen su competencia en este país, siendo
openaire   +2 more sources

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

open access: yesAdvanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen   +14 more
wiley   +1 more source

El adiós al precedente vinculante a favor del precedente

open access: yes, 2009
En el presente trabajo se analiza la sentencia que dejó sin efecto el precedente que estableció el “recurso de agravio a favor del precedente”. El autor considera que los presupuestos para emitir un precedente vinculante, establecidos en una sentencia anterior pero como obiter dictum, permiten adoptar una decisión como la tomada en este caso (que ...
openaire   +1 more source

Home - About - Disclaimer - Privacy