Results 51 to 60 of about 1,914,410 (330)

The Hydrological Cycle over a Wide Range of Climates Simulated with an Idealized GCM [PDF]

open access: yes, 2008
A wide range of hydrological cycles and general circulations was simulated with an idealized general circulation model (GCM) by varying the optical thickness of the longwave absorber.
O'Gorman, Paul A., Schneider, Tapio
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Pattern scaling using ClimGen: monthly-resolution future climate scenarios including changes in the variability of precipitation [PDF]

open access: yes, 2015
Development, testing and example applications of the pattern-scaling approach for generating future climate change projections are reported here, with a focus on a particular software application called “ClimGen”.
C Huntingford   +27 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Continuous Monitoring of Differential Reflectivity Bias for C-Band Polarimetric Radar Using Online Solar Echoes in Volume Scans

open access: yesRemote Sensing, 2019
The measurement error of differential reflectivity (ZDR), especially systematic ZDR bias, is a fundamental issue for the application of polarimetric radar data. Several calibration methods have been proposed and applied to correct ZDR bias.
Zhigang Chu   +4 more
doaj   +1 more source

Rainfall Estimates on a Gridded Network (REGEN) – a global land-based gridded dataset of daily precipitation from 1950 to 2016 [PDF]

open access: yesHydrology and Earth System Sciences, 2020
We present a new global land-based daily precipitation dataset from 1950 using an interpolated network of in situ data called Rainfall Estimates on a Gridded Network – REGEN.
S. Contractor   +13 more
doaj   +1 more source

Improving Precipitation Estimation Using Convolutional Neural Network [PDF]

open access: yes, 2019
Precipitation process is generally considered to be poorly represented in numerical weather/climate models. Statistical downscaling (SD) methods, which relate precipitation with model resolved dynamics, often provide more accurate precipitation estimates
AghaKouchak, A   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Optimal Ranking Regime Analysis of Intra- to Multidecadal U.S. Climate Variability. Part II: Precipitation and Streamflow [PDF]

open access: yes, 2014
In Part I of this paper, the optimal ranking regime (ORR) method was used to identify intradecadal to multidecadal (IMD) regimes in U.S. climate division temperature data during 1896–2012.
Cordero, Eugene C., Mauget, Steven A.
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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