Results 51 to 60 of about 102,033 (344)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A great enhancement of both strength and plasticity in a dual-phase high-entropy alloy by multi-effects of high carbon addition

Materials & Design, 2023
High-entropy alloys (HEAs) have become an interesting research area for the novel alloying design paradigm. Interstitial carbon has usually been introduced to enhance mechanical properties of HEAs. To achieve addition of high carbon, this work designed a
Conghui Hu, Jianlei Zhang, Yunhu Zhang, Changjiang Song, Qijie Zhai   +4 more
doaj   +1 more source

Response of the Asian Summer Monsoons to a High-latitude Thermal Forcing: Mechanisms and Nonlinearities [PDF]

, 2020
This study investigates mechanisms and nonlinearities in the response of the Asian Summer Monsoons (ASM) to high-latitude thermal forcings of different amplitudes.
Joshi, Manoj, Luterbacher, Jürg, Osborn, Timothy, Ratna, S. B., Talento, Stefanie   +4 more
core   +2 more sources

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Precipitation strengthening mechanisms in Cu/Ni alloyed steel

Cailiao gongcheng
The microstructural evolution and yield strength changes of medium-Mn steels with Cu， Ni， and Cu/Ni composite additions after aging at 500 ℃ are systematically compared using electron backscatter diffraction （EBSD）， transmission electron microscopy （TEM）
LAI Weiqiang, DING Fanglin, HU Bin, LUO Haiwen   +3 more
doaj   +1 more source

Influence of Vanadium on the Microstructure and Mechanical Properties of Medium-Carbon Steels for Wheels

Metals, 2018
Steels used for high-speed train wheels require a combination of high strength, toughness, and wear resistance. In 0.54% C-0.9% Si wheel steel, the addition of 0.075 or 0.12 wt % V can refine grains and increase the ferrite content and toughness ...
Pengfei Wang, Zhaodong Li, Guobiao Lin, Shitong Zhou, Caifu Yang, Qilong Yong   +5 more
doaj   +1 more source

Strengthening Mechanisms in CoCrFeNiX_0.4 (Al, Nb, Ta) High Entropy Alloys Fabricated by Powder Plasma Arc Additive Manufacturing

Nanomaterials, 2021
In high entropy alloys (HEAs), the addition of large-size atoms results in lattice distortion and further leads to solid solution strengthening or precipitation strengthening.
Yupeng Zhang, Qingkai Shen, Xizhang Chen, Subramanian Jayalakshmi, Ramachandra Arvind Singh, Sergey Konovalov, Vladislav B. Deev, Evgeny S. Prusov   +7 more
doaj   +1 more source

A Southern Hemispheric influence on the North Atlantic through a shallow atmospheric circulation response [PDF]

, 2017
Previous research has discussed the importance of meridional migrations of the North Atlantic Subtropical High (NASH) on U.S. precipitation patterns, but the mechanisms that control these meridionial migrations are virtually unknown.
Bowerman, Adam R.
core   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

Unveiling the Affect of Annealing Temperature on the Phase Transformations of Inconel 718 Superalloy Manufactured by Additive Manufacturing [PDF]

Iranian Journal of Materials Science and Engineering, 2023
Phase transformations and the evolution of hardness during elevated-temperature annealing of Inconel 718 superalloy manufactured by the laser powder bed fusion (L-PBF) were investigated. The microstructural evolution, elemental analysis, phase formation,
Sajad Ghaemifar, Hamed Mirzadeh
doaj